Evidence map›Paper›PMID 34061226›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2022

Large extracellular vesicles in the left atrial appendage in patients with atrial fibrillation-the missing link?

Andreas Zietzer, Baravan Al-Kassou, Paul Jamme, Verena Rolfes, Eva Steffen, Marko Bulic, Mohammed Rabiul Hosen, Philip Roger Goody, Vedat Tiyerili, Sebastian Zimmer and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Extracellular Vesicles in Atrial Fibrillation-State of the Art.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Andreas Zietzer *Medical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. andreas.zietzer@ukbonn.de.ORCID http://orcid.org/0000-0001-5759-7627
Baravan Al-Kassou *Medical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Paul JammeMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Verena RolfesInstitute of Innate Immunity, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Eva SteffenMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Marko BulicMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Mohammed Rabiul HosenMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Philip Roger GoodyMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Vedat TiyeriliMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Sebastian ZimmerMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Jan Wilko SchrickelMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Alexander SedaghatMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Bernardo S FranklinInstitute of Innate Immunity, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Nikos WernerMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Georg NickenigMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Felix JansenMedical Department II, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. felix.jansen@ukbonn.de.
University Hospital Bonn · DEUniversity of Bonn · DE

Funding

Deutsche Forschungsgemeinschaft 397484323 - TRR 259Deutsche Forschungsgemeinschaft JA 2351/2-1Deutsche Forschungsgemeinschaft WE 4139/8-1Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung. DGK16/2018Ernst und Berta Grimmke Stiftung (DE) 13/19Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn (DE) 2018-1A-07Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn (DE) 2018-4-03
6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most frequent arrhythmic disease in humans, which leads to thrombus formation in the left atrial appendage and stroke through peripheral embolization. Depending on their origin, large extracellular vesicles (lEVs) can exert pro-coagulant functions. In the present study, we investigated how different types of AF influence the levels of large EV subtypes in three distinct atrial localizations. Blood samples were collected from the right and left atrium and the left atrial appendage of 58 patients. 49% of the patients had permanent AF, 34% had non-permanent AF, and 17% had no history of AF. Flow cytometric analysis of the origin of the lEVs showed that the proportion of platelet-derived lEVs in the left atrial appendage was significantly higher in permanent AF patients compared to non-permanent AF. When we grouped patients according to their current heart rhythm, we also detected significantly higher levels of platelet-derived lEVs in the left atrial appendage (LAA) in patients with atrial fibrillation. In vitro studies revealed, that platelet activation with lipopolysaccharide (LPS) leads to higher levels of miR-222-3p and miR-223-3p in platelet-derived lEVs. Treatment with lEVs from LPS- or thrombin-activated platelets reduces the migration of endothelial cells in vitro. These results suggest that permanent atrial fibrillation is associated with increased levels of platelet-derived lEVs in the LAA, which are potentially involved in LAA thrombus formation.

Indexed as

AgedAtrial AppendageAtrial FibrillationEchocardiography, TransesophagealExtracellular VesiclesFemaleFlow CytometryHeart AtriaHumansMaleMicroscopy, ElectronPlatelet ActivationAtrial fibrillationEndothelial functionExtracellular vesiclemicroRNA-222-3pmicroRNA-223-3pMicrovesiclePlatelet

Identifiers

PMID34061226
PMCPMC8766378
OpenAlexW3164174262

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.