Evidence map›Paper›PMID 34061046›Full record

ArticlePhysics in medicine and biology2021

Optical scatter imaging of resected breast tumor structures matches the patterns of micro-computed tomography.

Samuel S Streeter, Benjamin W Maloney, Rebecca A Zuurbier, Wendy A Wells, Richard J Barth, Keith D Paulsen, Brian W Pogue

Open access · greenAbstract read
In one paragraph

Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Samuel S StreeterThayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.ORCID 0000-0001-8267-3556
Benjamin W MaloneyThayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.
Rebecca A ZuurbierDepartments of Radiology (RAZ), Pathology and Laboratory Medicine (WAW), and Surgery (RJB), Dartmouth-Hitchcock Medical Center, Lebanon NH 03756, United States of America.
Wendy A WellsDepartments of Radiology (RAZ), Pathology and Laboratory Medicine (WAW), and Surgery (RJB), Dartmouth-Hitchcock Medical Center, Lebanon NH 03756, United States of America.
Richard J BarthDepartments of Radiology (RAZ), Pathology and Laboratory Medicine (WAW), and Surgery (RJB), Dartmouth-Hitchcock Medical Center, Lebanon NH 03756, United States of America.
Keith D PaulsenThayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States of America.ORCID 0000-0002-9887-670X
Dartmouth College · USDartmouth–Hitchcock Medical Center · US

Funding

Optical Scatter Imaging System for Surgical Specimen Margin Assessment during Breast Conserving SurgeryR01CA192803 · NCI · DARTMOUTH COLLEGE · PI PAULSEN, KEITH D., POGUE, BRIAN WILLIAM · 2015 to 2019
$2.7M
NCI NIH HHS R01 CA192803
6 · The paper itself

Abstract

In patients undergoing breast-conserving surgery (BCS), the rate of re-excision procedures to remove residual tumor left behind after initial resection can be high. Projection radiography, and recently, volumetric x-ray imaging are used to assess margin adequacy, but x-ray imaging lacks contrast between healthy, abnormal benign, and malignant fibrous tissues important for surgical decision making. The purpose of this study was to compare micro-CT and optical scatter imagery of surgical breast specimens and to demonstrate enhanced contrast-to intra-tumoral morphologies and tumor boundary features revealed by optical scatter imaging. A total of 57 breast tumor slices from 57 patients were imaged

Indexed as

BreastBreast NeoplasmsFemaleHumansMargins of ExcisionMastectomy, SegmentalX-Ray Microtomographybreast cancerbreast-conserving surgerymicro-CToptical scatter imagingspatial frequency domain imaging

Identifiers

PMID34061046
PMCPMC9161376
OpenAlexW3163402017

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.