Evidence map›Paper›PMID 34060882›Full record

ArticleBehavioral neuroscience2021

Piecing together the orbitofrontal puzzle.

Catherine Elorette, Atsushi Fujimoto, J Megan Fredericks, Frederic M Stoll, Brian E Russ, Peter H Rudebeck

Abstract read
In one paragraph

Article in Behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Dissociable Representations of Decision Variables within Subdivisions of the Macaque Orbital and Ventrolateral Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Catherine EloretteNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine.ORCID 0000-0001-5735-4369
Atsushi FujimotoNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine.ORCID 0000-0002-1621-2003
J Megan FredericksNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine.ORCID 0000-0003-0385-1540
Frederic M StollNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine.ORCID 0000-0002-8642-8133
Brian E RussNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine.ORCID 0000-0003-0320-1257
Peter H RudebeckNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine.ORCID 0000-0002-1411-7555

Funding

Defining Neuronal Circuits and Cellular Processes Underlying Resting fMRI SignalsR01MH111439 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI MILHAM, MICHAEL PETER, SCHROEDER, CHARLES E · 2016 to 2020
$5.1M
Investigating the molecular, cellular and circuit effects of transcranial magnetic stimulationR01NS109498 · NINDS · UNIVERSITY OF MINNESOTA · PI FALCHIER, ARNAUD Y, OPITZ, ALEXANDER · 2019 to 2022
$3.2M
Mechanistic and causal basis of fMRI functional connectivity in non-human primatesRF1MH117040 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUDEBECK, PETER, RUSS, BRIAN E · 2018 to 2018
$2.8M
A new approach to the role of prefrontal-limbic circuits in anxiety disordersR01MH110822 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUDEBECK, PETER · 2016 to 2020
$2.2M
NIMHNIMH NIH HHS R01 MH110822NIMH NIH HHS R01 MH111439NIMH NIH HHS RF1 MH117040NINDSNINDS NIH HHS R01 NS109498Takeda Science Foundation
6 · The paper itself

Abstract

For almost a century, researchers have puzzled over how the orbitofrontal cortex (OFC) contributes to behavior. Our understanding of the functions of this area has evolved as each new finding and piece of information is added to complete the larger picture. Despite this, the full picture of OFC function is incomplete. Here we begin by reviewing recent (and not so recent) theories of how OFC contributes to behavior. We then go onto highlight emerging work that has helped to broaden perspectives on the role that OFC plays in contingent learning, interoception, and social behavior. How OFC contributes to these aspects of behavior is not well understood. Here we argue that only by establishing where and how these and other functions fit within the puzzle of OFC, either alone or as part of larger brain-wide circuits, will we be able to fully realize the functions of this area. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Indexed as

CognitionPrefrontal CortexLearning

Identifiers

PMID34060882
PMCPMC8476229

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.