ArticleBehavioral neuroscience2021
Cross-species studies on orbitofrontal control of inference-based behavior.
Article in Behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- The reward positivity is insensitive to reinforcer devaluation.Cognitive, affective & behavioral neuroscience · 2025Article
- Projecting neurons from the lateral entorhinal cortex to the basolateral amygdala mediate the encoding of incidental odor-taste associations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Individual differences in intolerance of uncertainty is primarily linked to the structure of inferior frontal regions.Cognitive, affective & behavioral neuroscience · 2025Article
- The reward positivity is insensitive to reinforcer devaluation.bioRxiv : the preprint server for biology · 2025Article
- Distinct roles of monkey OFC-subcortical pathways in adaptive behavior.Nature communications · 2024Article
- Modeling impaired insight after drug use in rodents.Behavioral neuroscience · 2024Review
- The cognitive (lateral) hypothalamus.Trends in cognitive sciences · 2024Review
- Distinct roles of monkey OFC-subcortical pathways in adaptive behavior.bioRxiv : the preprint server for biology · 2023Article
- Computationally Informed Interventions for Targeting Compulsive Behaviors.Biological psychiatry · 2023Review
- Anticipation: An Essential Feature of Anhedonia.Current topics in behavioral neurosciences · 2022Article
- Dopamine D1 and D2 Receptors Are Important for Learning About Neutral-Valence Relationships in Sensory Preconditioning.Frontiers in behavioral neuroscience · 2021Article
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2 authors.
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Abstract
Many decisions are guided by expectations about their outcomes. These expectations can arise from two fundamentally different sources: from direct experience with outcomes and the events and actions that precede them or from mental simulations and inferences when direct experience is missing. Here we discuss four elegant tasks from animal learning theory (devaluation, sensory preconditioning, Pavlovian-to-instrumental transfer, and Pavlovian overexpectation) and how they can be used to isolate behavior that is based on such mental simulations from behavior that can be based solely on experience. We then review findings from studies in rodents, nonhuman primates, and humans that use these tasks in combination with neural recording and loss-of-function experiments to understand the role of the orbitofrontal cortex (OFC) in outcome inference. The results of these studies show that activity in the OFC is correlated with inferred outcome expectations and that an intact OFC is necessary for inference-based behavior and learning. In summary, these findings provide converging cross-species support for the idea that the OFC is critical for behavior that is based on inferred outcomes, whereas it is not required when expectations can be based on direct experience alone. This conclusion may have important implications for our understanding of the role of OFC in psychiatric disorders and how we may be able to treat them. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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