SynthesisEuropean journal of neurology2021
Systematic review of cases of acute myelitis in individuals with COVID-19.
Synthesis in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- SARS-CoV-2 infection and spontaneous spinal hemorrhage: a systematic review.Neurosurgical review · 2023Pooled it
- Clinical characteristics, radiological features and prognostic factors of transverse myelitis following COVID-19 vaccination: A systematic review.Multiple sclerosis and related disorders · 2022Pooled it
- Systematic review of cases of acute myelitis in individuals with COVID-19.European journal of neurology · 2021Pooled it
- Do Long COVID and COVID Vaccine Side Effects Share Pathophysiological Picture and Biochemical Pathways?International journal of molecular sciences · 2025Review
- Acute transverse myelitis and associate vaccine complication in SARS-CoV-2 patients: a retrospective cohort analysis in real-world database.Virology journal · 2025Article
- Risk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States.PloS one · 2025Article
- Article
- COVID-19: Unveiling the Neuropsychiatric Maze-From Acute to Long-Term Manifestations.Biomedicines · 2024Review
- Atypical and delayed spinal cord MRI features of COVID-19-associated myelopathies: a report of four cases and literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Clinical and immunological features in patients with neuroimmune complications of COVID-19 during Omicron wave in China: a case series.Frontiers in immunology · 2024Article
- 'Grasshopper sign': the novel imaging of post-COVID-19 myelopathy with delayed longitudinal white matter abnormalities.BMJ neurology open · 2024Article
- Plasmapheresis in post-COVID-19 myelitis: A case report.Qatar medical journal · 2024Article
- Acute Necrotizing Myelitis Associated with COVID-19.Yonsei medical journal · 2023Article
- Article
- Encephalomyelitis associated with coronavirus disease 2019: a case report.Journal of medical case reports · 2022Article
- Myelitis Following COVID-19 Illness.Cureus · 2022Article
- Acute Ascending Necrotizing Myelitis After COVID-19 Infection: A Clinicopathologic Report.Neurology. Clinical practice · 2022Article
- COVID-19-induced longitudinal extensive myelitis.Turkish journal of physical medicine and rehabilitation · 2022Article
- Acute transverse myelitis progressing to permanent quadriplegia following COVID-19 infection.The American journal of emergency medicine · 2022Article
- Longitudinally extensive transverse myelitis (LETM) secondary to SARS-CoV-2 infection: A recent reality in spinal cord injury rehabilitation.Clinical case reports · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAn incremental number of cases of acute transverse myelitis (ATM) in individuals with ongoing or recent coronavirus disease 2019 (COVID-19) have been reported.
methodsA systematic review was performed of cases of ATM described in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by screening both articles published and in preprint.
resultsTwenty cases were identified. There was a slight male predominance (60.0%) and the median age was 56 years. Neurological symptoms first manifested after a mean of 10.3 days from the first onset of classical, mostly respiratory symptoms of COVID-19. Overall, COVID-19 severity was relatively mild. Polymerase chain reaction of cerebrospinal fluid for SARS-CoV-2 was negative in all 14 cases examined. Cerebrospinal fluid findings reflected an inflammatory process in most instances (77.8%). Aquaporin-4 and myelin oligodendrocyte protein antibodies in serum (tested in 10 and nine cases, respectively) were negative. On magnetic resonance imaging, the spinal cord lesions spanned a mean of 9.8 vertebral segments, necrotic-hemorrhagic transformation was present in three cases and two individuals had additional acute motor axonal neuropathy. More than half of the patients received a second immunotherapy regimen. Over a limited follow-up period of several weeks, 90% of individuals recovered either partially or near fully.
conclusionAlthough causality cannot readily be inferred, it is possible that cases of ATM occur para- or post-infectiously in COVID-19. All identified reports are anecdotal and case descriptions are heterogeneous. Whether the condition and the observed radiological characteristics are specific to SARS-CoV-2 infection needs to be clarified.
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