ArticleeLife2021
Rampant tooth loss across 200 million years of frog evolution.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- An Evolving View of Character Macroevolution.Systematic biology · 2026Review
- Beyond mammals: the evolution of chewing and other forms of oropharyngeal food processing in vertebrates.Biological reviews of the Cambridge Philosophical Society · 2026Review
- The metamorphic transition of the frog mouth: from tadpole keratinized mouthparts to adult teeth.Royal Society open science · 2025Article
- Reduction of Tooth Replacement Disproportionately Affects the Evolution of Enamel Matrix Proteins.Journal of molecular evolution · 2025Article
- Convergent Evolution Has Led to the Loss of Claw Proteins in Snakes and Worm Lizards.Genome biology and evolution · 2025Article
- Increasing the impact of vertebrate scientific collections through 3D imaging: The openVertebrate (oVert) Thematic Collections Network.Bioscience · 2024Review
- Unveiling vertebrate development dynamics in frog Xenopus laevis using micro-CT imaging.GigaScience · 2024Article
- Using salamanders as model taxa to understand vertebrate feeding constraints during the late Devonian water-to-land transition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Bat teeth illuminate the diversification of mammalian tooth classes.Nature communications · 2023Article
- The abundance, biomass, and distribution of ants on Earth.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Re-evaluating the morphological evidence for the re-evolution of lost mandibular teeth in frogs.Evolution; international journal of organic evolution · 2021Article
- Pseudogenized Amelogenin Reveals Early Tooth Loss in True Toads (Anura: Bufonidae).Integrative and comparative biology · 2021Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Teeth are present in most clades of vertebrates but have been lost completely several times in actinopterygian fishes and amniotes. Using phenotypic data collected from over 500 genera via micro-computed tomography, we provide the first rigorous assessment of the evolutionary history of dentition across all major lineages of amphibians. We demonstrate that dentition is invariably present in caecilians and salamanders, but teeth have been lost completely more than 20 times in frogs, a much higher occurrence of edentulism than in any other vertebrate group. The repeated loss of teeth in anurans is associated with a specialized diet of small invertebrate prey as well as shortening of the lower jaw, but it is not correlated with a reduction in body size. Frogs provide an unparalleled opportunity for investigating the molecular and developmental mechanisms of convergent tooth loss on a large phylogenetic scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.