ArticleeLife2021
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Risk factors of amyotrophic lateral sclerosis: a global meta-summary.Frontiers in neuroscience · 2023Pooled it
- Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature.Acta neuropathologica communications · 2022Pooled it
- De novo variants in KDM2A cause a syndromic neurodevelopmental disorder.American journal of human genetics · 2026Article
- TDP-43: unveiling the hidden key to cellular fate decisions.Cell communication and signaling : CCS · 2025Review
- Potential Predictors of Mortality in Adults with Severe Traumatic Brain Injury.Brain sciences · 2025Article
- Genetic Differences Modify Anesthetic Preconditioning of Traumatic Brain Injury in Drosophila.Journal of neurotrauma · 2025Article
- Screening, identification, and experimental validation of SUMOylation biomarkers in Parkinson's disease.Hereditas · 2025Article
- TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in amyotrophic lateral sclerosis and frontotemporal dementia.The Journal of clinical investigation · 2025Article
- Potential Correlation Between Molecular Biomarkers and Oxidative Stress in Traumatic Brain Injury.International journal of molecular sciences · 2025Review
- Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry.Brain sciences · 2025Article
- Nuclear pore dysfunction and disease: a complex opportunity.Nucleus (Austin, Tex.) · 2024Review
- Lactobacillus Eats Amyloid Plaque and Post-Biotically Attenuates Senescence Due to Repeat Expansion Disorder and Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2024Article
- Traumatic injury causes selective degeneration and TDP-43 mislocalization in human iPSC-derivedbioRxiv : the preprint server for biology · 2024Article
- dTBI2: A Calibrated, Tunable Device for Administering Traumatic Brain Injury in Drosophila.Current protocols · 2024Article
- Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD.Molecular neurodegeneration · 2024Review
- Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease.Cell death & disease · 2024Article
- Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice.Brain : a journal of neurology · 2023Article
- Nuclear transport proteins: structure, function, and disease relevance.Signal transduction and targeted therapy · 2023Review
- Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse.Acta neuropathologica communications · 2023Article
- Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import.Science advances · 2023Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Eric N AndersonDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, United States.
Andrés A MoreraDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, United States.
Sukhleen KourDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, United States.
Jonathan D CherryDepartment of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, United States.
Nandini RameshDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, United States.
Amanda GleixnerDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Jacob C SchwartzDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, United States.
Christopher EbmeierMolecular, Cellular & Developmental Biology, University of Colorado, Boulder, United States.ORCID 0000-0001-7940-6190
William OldMolecular, Cellular & Developmental Biology, University of Colorado, Boulder, United States.
Christopher J DonnellyDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID 0000-0002-2383-9015
Jeffrey P ChengPhysical Medicine & Rehabilitation; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, United States.
Anthony E KlinePhysical Medicine & Rehabilitation; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, United States.
Julia KoflerDepartment of Pathology, University of Pittsburgh, Pittsburgh, United States.
Thor D SteinDepartment of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, United States.
Udai Bhan PandeyDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, United States.ORCID 0000-0002-6267-0179
University of Pittsburgh · USChildren's Hospital of Pittsburgh · USAllen Institute for Brain Science · USBoston University · USUniversity of Arizona · US
Funding
Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical SyndromesU54NS115266 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2019 to 2023
$10.3MTraining in the Neurobiology of Neurological DiseaseT32NS086749 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Omar El Gharbawie, REBECCA P SEAL · 2014 to 2026
$4.8MOptimizing Environmental Enrichment to Model Preclinical NeurorehabilitationR01NS084967 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLINE, ANTHONY E. · 2014 to 2025
$3.7MCellular and Molecular Mechanisms of FUS-related Amyotrophic Lateral SclerosisR01NS081303 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PANDEY, UDAI B · 2013 to 2023
$3.6MAnalysis of the RNA-binding Protein FUS and Its Role in Neurodegenerative DiseaseR00NS082376 · NINDS · UNIVERSITY OF ARIZONA · PI SCHWARTZ, JACOB C. · 2015 to 2017
$771kIntranasal delivery of neural stem cells alone or in combination with environmental enrichment as a potential therapy for experimental TBIR56NS113810 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GUTOVA, MARGARITA, KLINE, ANTHONY E. · 2020 to 2020
$430kNuclear export inhibition as a novel therapeutic target for C9ORF72 ALS/FTDR21NS098379 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONNELLY, CHRISTOPHER JAMES, PANDEY, UDAI B · 2017 to 2018
$429kOligonucleotide approach to antagonize neurotoxic TDP-43 assemblies in dementiaR21AG064940 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONNELLY, CHRISTOPHER JAMES, PANDEY, UDAI B · 2019 to 2020
$417kNIA NIH HHS R21 AG064940NINDS NIH HHS R00 NS082376NINDS NIH HHS R01 NS081303NINDS NIH HHS R01 NS084967NINDS NIH HHS R21 NS098379NINDS NIH HHS R56 NS113810NINDS NIH HHS U54 NS115266
Abstract
Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy (CTE). Although defects in nucleocytoplasmic transport (NCT) is reported ALS and other neurodegenerative diseases, whether defects in NCT occur in TBI remains unknown. We performed proteomic analysis on
Indexed as
Active Transport, Cell NucleusAnimalsAnimals, Genetically ModifiedBrainBrain Injuries, TraumaticCase-Control StudiesDisease Models, AnimalDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsGTPase-Activating ProteinsHEK293 CellsHumansLongevityMaleMembrane GlycoproteinsDNA-Binding ProteinsDrosophila ProteinsGTPase-Activating ProteinsMembrane GlycoproteinsNuclear Pore Complex Proteinsnuclear pore protein p62Nup214 protein, DrosophilaProtein AggregatesRanGAP protein, DrosophilaTARDBP protein, humanTardbp protein, ratTBPH protein, Drosophilaamyotrophic lateral sclerosischronic traumatic encephalopathyD. melanogastergeneticsgenomicshumanneurodegenerationneuroscienceratTDP-43
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.