Evidence map›Paper›PMID 34060342›Full record

ArticleThe Annals of otology, rhinology, and laryngology2022

Thyroidectomy for Graves' Disease Predicts Postoperative Neck Hematoma and Hypocalcemia: A North American cohort study.

Sadaf Mohtashami, Keith Richardson, Veronique-Isabelle Forest, Alex Mlynarek, Richard J Payne, Michael Tamilia, Marc P Pusztaszeri, Michael P Hier, Nader Sadeghi, Marco A Mascarella

Open access · hybridAbstract read
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In one paragraph

Article in The Annals of otology, rhinology, and laryngology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sadaf MohtashamiDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-6841-0351
Keith RichardsonDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada.
Veronique-Isabelle ForestDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada.
Alex MlynarekDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada.
Richard J PayneDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada.
Michael TamiliaDivision of Endocrinology, Department of Medicine, McGill University, Montreal, QC, Canada.
Marc P PusztaszeriDepartment of Pathology, McGill University, Montreal, QC, Canada.
Michael P HierDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada.
Nader SadeghiDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada.
Marco A MascarellaDepartment of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-8880-805X
McGill University · CAJewish General Hospital · CAMcGill University Health Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveExamine the association of Graves' disease with the development of postoperative neck hematoma.

designA cohort of patients participating in the Thyroid Procedure-Targeted Database of the National Surgical Quality Improvement Program from January 1, 2016 to December 31, 2018.

settingA North American surgical cohort study.

methods17 906 patients who underwent thyroidectomy were included. Propensity score matching was performed to adjust for differences in baseline covariates. Multivariate logistic regression was used to ascertain the association between thyroidectomy for Graves' disease and risk of postoperative adverse events within 30 days of surgery. The primary outcome was postoperative hematoma. Secondary outcomes were postoperative hypocalcemia and recurrent laryngeal nerve injury.

resultsOne-to-three propensity score matching yielded 1207 patients with mean age (SD) of 42.6 (14.9) years and 1017 (84.3%) female in the group with Graves' disease and 3621 patients with mean age (SD) of 46.7 (15.0%) years and 2998 (82.8%) female in the group with indications other than Graves' disease for thyroidectomy. The cumulative 30-day incidence of postoperative hematoma was 3.1% (38/1207) in the Graves' disease group and 1.9% (70/3621) in other patients. The matched cohort showed that Graves' disease was associated with higher odds of postoperative hematoma (OR 1.65, 95% CI 1.10-2.46) and hypocalcemia (OR 2.04, 95% CI 1.66-2.50) compared with other indications for thyroid surgery. There was no difference in recurrent laryngeal nerve injury among the 2 groups.

conclusionsPatients with Graves' disease undergoing thyroidectomy are more likely to suffer from postoperative hematoma and hypocalcemia compared to patients undergoing surgery for other indications.

Indexed as

AdultCohort StudiesDatabases, FactualFemaleGraves DiseaseHead and Neck NeoplasmsHematomaHumansHypocalcemiaIncidenceMaleMiddle AgedNorth AmericaPostoperative ComplicationsPropensity ScoreQuality ImprovementGraves’ diseasehematomahypocalcemiarecurrent laryngeal nerve injurythyroidectomy

Identifiers

PMID34060342
PMCPMC8899812
OpenAlexW3165647892

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.