Evidence map›Paper›PMID 34060331›Full record

ArticlemBio2021

Genome Scale Analysis Reveals IscR Directly and Indirectly Regulates Virulence Factor Genes in Pathogenic

David Balderas, Erin Mettert, Hanh N Lam, Rajdeep Banerjee, Tomas Gverzdys, Pablo Alvarez, Geetha Saarunya, Natasha Tanner, Adam Zoubedi, Yahan Wei and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Small RNA OxyS induces resistance to aminoglycosides during oxidative stress by controlling Fe-S cluster biogenesis inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Fe-S cluster homeostasis and beyond: The multifaceted roles of IscR.Biochimica et biophysica acta. Molecular cell research · 2024
    Review
  7. Article
  8. CysB Is a Key Regulator of the Antifungal Activity ofInternational journal of molecular sciences · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

David BalderasDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Erin MettertDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Hanh N LamDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Rajdeep BanerjeeDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Tomas GverzdysDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Pablo AlvarezDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Geetha SaarunyaDepartment of Biological Sciences, University of South Carolina, Columbia, South Carolina, USA.
Natasha TannerDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Adam ZoubediDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Yahan WeiDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
Patricia J KileyDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Victoria AuerbuchDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
University of California, Santa Cruz · USUniversity of Wisconsin–Madison · USUniversity of South Carolina · US

Funding

UCSC Research Mentoring Internship Program: An Initiative to Increase Diversity and Inclusion in Genomics ResearchR25HG006836 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BROOKS, ANGELA NORIE, RAMON, MARINA L · 2013 to 2025
$3.7M
Host iron and Yersinia pathogenesisR01AI119082 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STONE, VICTORIA AUERBUCH · 2016 to 2020
$2.5M
NHGRI NIH HHS R25 HG006836NIAID NIH HHS R01 AI119082
6 · The paper itself

Abstract

The iron-sulfur cluster coordinating transcription factor IscR is important for the virulence of Yersinia pseudotuberculosis and a number of other bacterial pathogens. However, the IscR regulon has not yet been defined in any organism. To determine the

Indexed as

Genome, BacterialBacterial ProteinsBinding SitesGene Expression Regulation, BacterialGenomicsHumansIronPromoter Regions, GeneticVirulenceVirulence FactorsYersinia pestisYersinia pseudotuberculosisYersinia pseudotuberculosis InfectionsBacterial ProteinsIronVirulence FactorsChIP-SeqIscRRNA-SeqYersiniaYersinia pestisYersinia pseudotuberculosis

Identifiers

PMID34060331
PMCPMC8262890
OpenAlexW3165155683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.