Evidence map›Paper›PMID 34060062›Full record

ArticleBiological trace element research2022

Harmful Effects of Inorganic Mercury Exposure on Kidney Cells: Mitochondrial Dynamics Disorder and Excessive Oxidative Stress.

Biqi Han, Zhanjun Lv, Xuemin Han, Siyu Li, Bing Han, Qingyue Yang, Xiaoqiao Wang, Pengfei Wu, Jiayi Li, Ning Deng and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 89 citations in OpenAlex.

  1. Ellagic acid counteracts mercury chloride-induced oxidative stress and thiol oxidation in Drosophila melanogaster.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Article
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  9. A Fluorescent Probe for HgJournal of fluorescence · 2025
    Article
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  12. Review
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  19. Review
  20. Resveratrol Has Histone 4 and Beta-Defensin 1-Mediated Favorable Biotherapeutic Effects on Liver and Other Target Organs in Diabetic Rats.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Biqi HanCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China.
Zhanjun LvCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China.
Xuemin HanCenter for Animal Disease Control and Prevention of Chifeng, Chifeng, 024000, China.
Siyu LiCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China.
Bing HanCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China.
Qingyue YangCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China.
Xiaoqiao WangCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China.
Pengfei WuCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China.
Jiayi LiCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China.
Ning DengCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China.
Zhigang ZhangCollege of Veterinary Medicine, Northeast Agricultural University, No. 600 Changjiang Road, Harbin, 150030, China. zhangzhigang@neau.edu.cn.ORCID http://orcid.org/0000-0002-4974-5850
Northeast Agricultural University · CNChifeng University · CN

Funding

National Natural Science Foundation of China 31972754
6 · The paper itself

Abstract

Mercury is widely used in industry and has caused global environmental pollution. Inorganic mercury accumulates in the body causes damage to many organs, and the kidney is the most susceptible to the toxic effects of mercury. However, the underlying specific molecular mechanism of renal injury induced by inorganic mercury remains unclear at the cellular level. Therefore, in order to understand its molecular mechanism, we used in vitro method. We established experimental models by treating human embryonic kidney epithelial cell line (HEK-293 T) cells with HgCl

Indexed as

MercuryMitochondrial DiseasesEpithelial CellsHEK293 CellsHumansKidneyMitochondrial DynamicsOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSirtuin 1MercuryPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSirtuin 1HgCl2Kidney cellMitochondrial dynamics dysfunctionROSSirt1/PGC-1α

Identifiers

PMID34060062
OpenAlexW3165302532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.