Evidence map›Paper›PMID 34060017›Full record

ArticleEnvironmental science and pollution research international2021

Cytotoxicity, oxidative stress, and apoptosis in human embryonic kidney (HEK293) and colon cancer (SW480) cell lines exposed to nanoscale zeolitic imidazolate framework 8 (ZIF-8).

Seyed Ali Johari, Mehrdad Sarkheil, Shakila Veisi

Abstract read
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Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seyed Ali JohariDepartment of Fisheries, Faculty of Natural Resources, University of Kurdistan, P.O. Box 416, Sanandaj, 66177-15175, Iran. a.johari@uok.ac.ir.ORCID http://orcid.org/0000-0002-1210-5454
Mehrdad SarkheilDepartment of Fisheries, Faculty of Natural Resources and Environment, Ferdowsi University of Mashhad, Mashhad, Iran.
Shakila VeisiDepartment of Fisheries, Faculty of Natural Resources, University of Kurdistan, P.O. Box 416, Sanandaj, 66177-15175, Iran.

Funding

University of Kurdistan GRC98-06503-1
6 · The paper itself

Abstract

Zinc (zeolitic) imidazolate framework 8 (ZIF-8) has been widely considered in the literature as an ideal candidate for drug delivery especially anti-cancer drugs. However, the available information on the biocompatibility and cytotoxicity of ZIF-8 nanoparticles is contradictory. Therefore, in the present study, the ZIF-8 particles were synthetized, characterized, and their potential toxicity on two eukaryotic cell lines including human embryonic kidney (HEK293) and human colon cancer (SW480) cells was investigated in vitro. The characterization of ZIF-8 particles by TEM, EDX, SEM, and DLS indicated the synthesis of the hexagonal crystals with mean diameter of 124.71±32.74 nm and the presence of the zinc element at 86.25% by weight (wt%) of the ZIF-8 structure. The results of the cytotoxicity assessment of ZIF-8 NPs showed that the viability of two different cell lines reduced significantly coincident with increasing exposure concentration from 0 to 500 μg mL

Indexed as

Colonic NeoplasmsZeolitesApoptosisHEK293 CellsHumansKidneyOxidative StressZeolitesAnti-cancerAntineoplasticApoptosisCytotoxicityReactive oxygen speciesZeolitic imidazolate framework

Identifiers

PMID34060017

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.