ArticleScientific reports2021
The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Determining risk factors predicting miscarriage among couples undergoing assisted reproductive treatment: a systematic review.BMC pregnancy and childbirth · 2026Pooled it
- Retrospective Analysis of 1168 Cases of Ovular Decidual Tissue from First-Trimester Abortions: Proposal for a Histopathological Diagnostic Framework.Diagnostics (Basel, Switzerland) · 2026Article
- Analysis of controlled ovarian hyperstimulation protocols in women over 35 years old with poor ovarian response: a real-world study.BMC pregnancy and childbirth · 2023Article
- Is there a relationship between assisted reproductive technology and maternal outcomes? A systematic review of cohort studies.International journal of reproductive biomedicine · 2023Review
- How Much Is an Abortion Worth? Was a Human "Not Formed"? An Italian Proposal.Healthcare (Basel, Switzerland) · 2023Article
- VaginalMicrobiology spectrum · 2022Article
- Non-linear Relationship of Maternal Age With Risk of Spontaneous Abortion: A Case-Control Study in the China Birth Cohort.Frontiers in public health · 2022Article
- Early Spontaneous Abortion in Fresh- and Frozen-Embryo Transfers: An Analysis of Over 35,000 Transfer Cycles.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We explored the independent risk factors associated with cases of spontaneous abortion in infertile patients treated with human-assisted reproductive technology (ART) and established a smooth curve fit and perform a threshold effect analysis can provide guidance and a valuable reference for predicting the probability of spontaneous abortion. This was a retrospective cohort study of 16,097 patients successfully conceived with ART in Shangqiu First People's Hospital from June 2013 to December 2018. Overall, 2,378 (14.77%) had an abortion and 13,719 (85.23%) did not have an abortion. Multivariate logistic regression analysis showed that female age (OR 1.050; 95% CI 1.032-1.069; P < 0.001), male age (OR 1.100; 95% CI 1.086-1.115; P < 0.001), follicular-stimulating hormone (OR 1.049; 95% CI 1.022-1.076; P < 0.001), anti-Mullerian hormone (OR 0.893; 95% CI 0.862-0.925; P < 0.001) and the number of fetuses at pregnancy diagnosis were independent factors associated with spontaneous abortion. The threshold effect analysis found that when female age > 32 years (cut-off point) old, age and the risk of spontaneous abortion were positively correlated. When follicular-stimulating hormone > 6.1 IU/L (cut-off point), follicular-stimulating hormone was positively correlated with the occurrence of spontaneous abortion, When anti-Mullerian hormone ≤ 3.1 ng/mL (cut-off point), anti-Mullerian hormone was negatively correlated with the occurrence of spontaneous abortion and there was a linear positive correlation between antral Follicle Counting and live birth. In addition, the older the male age, the higher the incidence of abortion. The smooth curve fit and threshold effect analyses can provide a more detailed estimate of the probability of spontaneous abortion for pregnant couples.
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