ArticleCommunications biology2021
Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DNA methylation aging and transcriptomic studies in horses.Nature communications · 2022Pooled it
- Advancing Marine Mammal Conservation Through Omics Tools and Integration of Indigenous Ecological Knowledge.Molecular ecology · 2026Review
- Review
- Prospects of multipurpose biomonitoring for fisheries assessment based on environmental nucleic acids.Journal of fish biology · 2026Review
- Non-Invasive Measures of DNA Methylation Capture Molecular Aging in Wild Capuchin Monkeys.Molecular ecology · 2026Article
- Epigenetic Age Estimation for Hawaiian False Killer Whales (Pseudorca crassidens) in the Absence of 'Known-Age' Individuals.Molecular ecology resources · 2026Article
- Investigating epigenetic biomarkers of age, sex, and disease in captive South African cheetahs (Acinonyx jubatus jubatus).PloS one · 2026Article
- Imaging and Diagnostic Tools for Cetacean Mammary Gland Assessment: Challenges and Future Directions for Marine Mammal Pathology, Medicine and Research.Journal of mammary gland biology and neoplasia · 2025Review
- Social bonds decrease epigenetic age in male bottlenose dolphins.Communications biology · 2025Article
- Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (Ecology and evolution · 2025Article
- Dental aging offers new insights to the first epigenetic clock for common dolphins (bioRxiv : the preprint server for biology · 2025Article
- Designing Epigenetic Clocks for Wildlife Research.Molecular ecology resources · 2025Review
- Estimating Polar Bear (Ecology and evolution · 2025Article
- Enhancing epigenetic aging clocks in cetaceans: accurate age estimations in small endangered delphinids, killer whales, pilot whales, belugas, humpbacks, and bowhead whales.Scientific reports · 2025Article
- Application of DNA Methylation-Based Age Estimation to Construct an Age Structure of Humpback Whales in a Newly Emerged Wintering Ground Around Hachijojima Island, Tokyo Metropolis, Japan.Ecology and evolution · 2025Article
- Environmental DNA Epigenetics Accurately Predicts the Age of Cultured Fish Larvae.Ecology and evolution · 2025Article
- TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction.Nature aging · 2024Article
- Article
- Pan-primate studies of age and sex.GeroScience · 2023Article
- Using epigenetic clocks to investigate changes in the age structure of critically endangered Māui dolphins.Ecology and evolution · 2023Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of a precise blood or skin tissue DNA Epigenetic Aging Clock for Odontocete (OEAC) would solve current age estimation inaccuracies for wild odontocetes. Therefore, we determined genome-wide DNA methylation profiles using a custom array (HorvathMammalMethyl40) across skin and blood samples (n = 446) from known age animals representing nine odontocete species within 4 phylogenetic families to identify age associated CG dinucleotides (CpGs). The top CpGs were used to create a cross-validated OEAC clock which was highly correlated for individuals (r = 0.94) and for unique species (median r = 0.93). Finally, we applied the OEAC for estimating the age and sex of 22 wild Norwegian killer whales. DNA methylation patterns of age associated CpGs are highly conserved across odontocetes. These similarities allowed us to develop an odontocete epigenetic aging clock (OEAC) which can be used for species conservation efforts by provide a mechanism for estimating the age of free ranging odontocetes from either blood or skin samples.
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