Evidence map›Paper›PMID 34059739›Full record

ArticleScientific reports2021

Converting tabular data into images for deep learning with convolutional neural networks.

Yitan Zhu, Thomas Brettin, Fangfang Xia, Alexander Partin, Maulik Shukla, Hyunseung Yoo, Yvonne A Evrard, James H Doroshow, Rick L Stevens

Erratum issuedAbstract readEvaluation Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. [Medical prior-guided TabMap deep learning model for ovarian cancer prediction and interpretability analysis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
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  9. Neural Latent Filtering for Gene Discovery in Breast Cancer Subtypes.Biotechnology reports (Amsterdam, Netherlands) · 2026
    Article
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  14. Article
  15. Article
  16. Article
  17. Deep Learning of Cellular Metabolic Flux Distributions Predicts Lifespan.bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yitan ZhuComputing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, 60439, USA. yitan.zhu@anl.gov.
Thomas BrettinComputing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, 60439, USA.
Fangfang XiaComputing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, 60439, USA.
Alexander PartinComputing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, 60439, USA.
Maulik ShuklaComputing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, 60439, USA.
Hyunseung YooComputing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, 60439, USA.
Yvonne A EvrardFrederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, 21702, USA.
James H DoroshowDevelopmental Therapeutics Branch, National Cancer Institute, Bethesda, MD, 20892, USA.
Rick L StevensComputing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, 60439, USA.

Funding

Phase 01 Clinical TrialsZIABC011078 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DOROSHOW, JAMES · 2009 to 2025
$9.0M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Convolutional neural networks (CNNs) have been successfully used in many applications where important information about data is embedded in the order of features, such as speech and imaging. However, most tabular data do not assume a spatial relationship between features, and thus are unsuitable for modeling using CNNs. To meet this challenge, we develop a novel algorithm, image generator for tabular data (IGTD), to transform tabular data into images by assigning features to pixel positions so that similar features are close to each other in the image. The algorithm searches for an optimized assignment by minimizing the difference between the ranking of distances between features and the ranking of distances between their assigned pixels in the image. We apply IGTD to transform gene expression profiles of cancer cell lines (CCLs) and molecular descriptors of drugs into their respective image representations. Compared with existing transformation methods, IGTD generates compact image representations with better preservation of feature neighborhood structure. Evaluated on benchmark drug screening datasets, CNNs trained on IGTD image representations of CCLs and drugs exhibit a better performance of predicting anti-cancer drug response than both CNNs trained on alternative image representations and prediction models trained on the original tabular data.

Indexed as

Deep LearningImage Processing, Computer-AssistedSoftwareCell Line, TumorHumans

Identifiers

PMID34059739
PMCPMC8166880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.