ArticleNature communications2021
Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 268 citations in OpenAlex.
- Spectral sensing at a glance.Nature communications · 2026Article
- Single-Nanoparticle Detection Using Quasi-Bound States in the Continuum Supported by Silicon Metasurfaces.Small methods · 2026Article
- Active Switching Between Absorption and Polarization Conversion Enabled with VONanomaterials (Basel, Switzerland) · 2026Article
- High-order photonic degeneracy enables topological reconfiguration in bound states in the continuum.Nature communications · 2026Article
- Direct imaging-based gradient metasurface sensor enabling spectrometer-free ultrasensitive biomolecule detection.Nature communications · 2026Article
- Reconfigurable chiroptical metasurface sensors enabled by bound states in the continuum.iScience · 2026Article
- Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics.Lab on a chip · 2026Review
- Nanotechnology-mediated strategies for skeletal muscle repair and regeneration: targeted intervention, functional remodeling, and translational challenges.Journal of nanobiotechnology · 2026Review
- Extreme sensitivity label-free biosensing platform based on topologically disruptive phase nano-optics.Microsystems & nanoengineering · 2026Article
- Article
- Bound states in the continuum: From fundamental physics to emerging photonic paradigms.iScience · 2026Review
- Article
- All dielectric etalon based metasurfaces optimized for high FOM refractive index sensing.Scientific reports · 2025Article
- Multispectral Chiral Quasi-Bound States in the Continuum Enabled Microfluidics for High-Throughput Molecular Screening and Quantification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Unlocking the Translational Potential of Nanophotonic Biosensors: Perspectives on Application-Guided Design.ACS photonics · 2025Review
- AI‑driven photonic noses: from conventional sensors to cloud‑to-edge intelligent microsystems.Microsystems & nanoengineering · 2025Review
- Nanoporous-structured metasurface refractive index sensor employing quasi-bound states in the continuum.Scientific reports · 2025Article
- Refractive Index Sensing Properties of Metal-Dielectric Yurt Tetramer Metasurface.Nanomaterials (Basel, Switzerland) · 2025Article
- Dual-band high-Q quasi-BIC metasurface for refractive index sensing.Nanophotonics (Berlin, Germany) · 2025Article
- Nanoplasmonic Sensing of Heterogeneous Extracellular Vesicles: From Bulk to Single Vesicles.Small methods · 2025Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biosensors are indispensable tools for public, global, and personalized healthcare as they provide tests that can be used from early disease detection and treatment monitoring to preventing pandemics. We introduce single-wavelength imaging biosensors capable of reconstructing spectral shift information induced by biomarkers dynamically using an advanced data processing technique based on an optimal linear estimator. Our method achieves superior sensitivity without wavelength scanning or spectroscopy instruments. We engineered diatomic dielectric metasurfaces supporting bound states in the continuum that allows high-quality resonances with accessible near-fields by in-plane symmetry breaking. The large-area metasurface chips are configured as microarrays and integrated with microfluidics on an imaging platform for real-time detection of breast cancer extracellular vesicles encompassing exosomes. The optofluidic system has high sensing performance with nearly 70 1/RIU figure-of-merit enabling detection of on average 0.41 nanoparticle/µm
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.