ArticleHorticulture research2021
Melatonin-induced DNA demethylation of metal transporters and antioxidant genes alleviates lead stress in radish plants.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 86 citations in OpenAlex.
- Melatonin-enabled omics: understanding plant responses to single and combined abiotic stresses for climate-smart agriculture.GM crops & food · 2026Review
- RsWRKY15-RsPDR12 module regulates Cd uptake and accumulation by promoting Cd efflux in radish (Raphanus sativus L.).Molecular horticulture · 2026Article
- Stabilization of the MAPK-Epigenetic Signaling Axis Underlies the Protective Effect of Thyme Oil Against Cadmium Stress in Root Meristem Cells ofInternational journal of molecular sciences · 2025Article
- DNA methylation changes in Medicago sativa under salt-alkaline stress and the function of 5-azacytidine in enhancing stress tolerance.BMC plant biology · 2025Article
- Review
- The Transcription Factor Basic Pentacysteine 5, RsBPC5, Enhances Lead Stress Tolerance inPlants (Basel, Switzerland) · 2025Article
- Melatonin Mitigates Cd-Induced Growth Repression and RNA mPlants (Basel, Switzerland) · 2025Article
- Xyloglucan endotransglucosylase/hydrolase 25 positively regulates the lead tolerance inFrontiers in plant science · 2025Article
- Unravelling the Epigenetic Code: DNA Methylation in Plants and Its Role in Stress Response.Epigenomes · 2024Review
- Underlying mechanism of Dendrobium huoshanense resistance to lead stress using the quantitative proteomics method.BMC plant biology · 2024Article
- Melatonin: The Multifaceted Molecule in Plant Growth and Defense.International journal of molecular sciences · 2024Review
- Multicontamination Toxicity Evaluation in the Model PlantPlants (Basel, Switzerland) · 2024Article
- 5-Aminolevulinic acid improves cold resistance through regulation of SlMYB4/SlMYB88-SlGSTU43 module to scavenge reactive oxygen species in tomato.Horticulture research · 2024Article
- Exogenous melatonin alleviates nicosulfuron toxicity by regulating the growth, photosynthetic capacity, and antioxidative defense of sweet corn seedlings.Photosynthetica · 2024Article
- Epigenetic Control of Plant Response to Heavy Metals.Plants (Basel, Switzerland) · 2023Review
- Pan-genome of Citrullus genus highlights the extent of presence/absence variation during domestication and selection.BMC genomics · 2023Article
- Article
- Melatonin: Current status and future perspectives in horticultural plants.Frontiers in plant science · 2023Review
- The role of epigenetic and epitranscriptomic modifications in plants exposed to non-essential metals.Frontiers in plant science · 2023Review
- DNA hypermethylation promotes the flowering of orchardgrass during vernalization.Plant physiology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Melatonin (MT) is a tryptophan-derived natural product that plays a vital role in plant response to abiotic stresses, including heavy metals (HMs). However, it remains elusive how exogenous MT mediates lead (Pb) accumulation and detoxification at the methylation and transcriptional levels in radish. In this study, decreased Pb accumulation and increased antioxidant enzyme activity were detected under MT treatment in radish. Single-base resolution maps of DNA methylation under Pb stress (Pb200) and Pb plus MT treatment (Pb_50MT) were first generated. The genome-wide methylation level was increased under Pb stress, while an overall loss of DNA methylation was observed under MT treatment. The differentially methylated region (DMR)-associated genes between Pb_50MT and Pb200 were uniquely enriched in ion binding terms, including cation binding, iron ion binding, and transition metal ion binding. Hyper-DMRs between Pb200 and Control exhibited a decreasing trend of methylation under Pb_50MT treatment. A few critical upregulated antioxidant genes (e.g., RsAPX2, RsPOD52 and RsGST) exhibited decreased methylation levels under MT treatment, which enabled the radish plants to scavenge lead-induced reactive oxygen species (ROS) and decrease oxidative stress. Notably, several MT-induced HM transporter genes with low methylation (e.g., RsABCF5, RsYSL7 and RsHMT) and transcription factors (e.g., RsWRKY41 and RsMYB2) were involved in reducing Pb accumulation in radish roots. These findings could facilitate comprehensive elucidation of the molecular mechanism underlying MT-mediated Pb accumulation and detoxification in radish and other root vegetable crops.
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Registered trials
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