ArticleMedicina intensiva
Histopathological features in fatal COVID-19 acute respiratory distress syndrome.
Article in Medicina intensiva. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Long-term cardiovascular complications in COVID-19 survivors according to disease severity.Scientific reports · 2025Article
- A Child with COVID-19 Complicated by Rapidly Progressive Severe Organizing Pneumonia: A Case Report.Hawai'i journal of health & social welfare · 2024Article
- Cell Cross-Talk in Alveolar Microenvironment: From Lung Injury to Fibrosis.American journal of respiratory cell and molecular biology · 2024Review
- Early lung autopsy in deceased patients with acute respiratory distress syndrome due to infection by SARS-CoV-2.Medicina intensiva · 2023Article
- [Early lung autopsy in deceased patients with acute respiratory distress syndrome due to infection by SARS-CoV-2].Medicina intensiva · 2023Article
- Evaluation of serum complement C4 among COVID-19 patients in Khartoum state: a case control-based study.F1000Research · 2023Article
- Risk factors for mortality in patients with COVID-19 needing extracorporeal respiratory support.The European respiratory journal · 2022Article
- Pathological Findings Associated With SARS-CoV-2 on Postmortem Core Biopsies: Correlation With Clinical Presentation and Disease Course.Frontiers in medicine · 2022Article
- Article
- Post-COVID-19 Lung Transplantation Italian Pivotal Protocol: Some Ethical Considerations.Transplantation proceedingsArticle
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOVID-19 acute respiratory distress syndrome (ARDS) shares the common histological hallmarks with other forms of ARDS. However, the chronology of the histological lesions has not been well established.
objectiveTo describe the chronological histopathological alterations in the lungs of patients with COVID-19 related ARDS.
designA prospective cohort study was carried out.
settingIntensive Care Unit of a tertiary hospital. PATIENTS: The first 22 consecutive COVID-19 deaths. MEASUREMENTS: Lung biopsies and histopathological analyses were performed in deceased patients with COVID-19 related ARDS. Clinical data and patient course were evaluated.
resultsThe median patient age was 66 [63-74] years; 73% were males. The median duration of mechanical ventilation was 17 [8-24] days. COVID-19 induced pulmonary injury was characterized by an exudative phase in the first week of the disease, followed by a proliferative/organizing phase in the second and third weeks, and finally an end-stage fibrosis phase after the third week. Viral RNA and proteins were detected in pneumocytes and macrophages in a very early stage of the disease, and were no longer detected after the second week. LIMITATION: Limited sample size.
conclusionsThe chronological evolution of COVID-19 lung histopathological lesions seems to be similar to that seen in other forms of ARDS. In particular, lung lesions consistent with potentially corticosteroid-sensitive lesions are seen.
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