ArticleeLife2021
An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- Growth-rate coordination across the width of a leaf preserves its flatness.PLoS biology · 2026Article
- Time-dependent bistability leads to critical slowing down during floral transition in Arabidopsis.Nature communications · 2026Article
- Auxin promotes robust founder cell specification during Arabidopsis lateral root initiation.Genetics · 2026Article
- Does genetic variation in controlled experiments predict phenology of wild plants?Journal of evolutionary biology · 2026Article
- Gene body methylation buffers noise in gene expression in plants.Nucleic acids research · 2026Article
- Genome-wide association study identifies key loci and candidate genes for seed vigor in upland cotton (Frontiers in plant science · 2026Article
- QUIRKY controls seed germination via precision degradation of ABI5.Science advances · 2025Article
- Self-organization underlies developmental robustness in plants.Cells & development · 2025Review
- Building resilience by cultivating difference: A role for noise in development.Current opinion in plant biology · 2025Review
- Establishment and maintenance of NRT2.1 inter-individual variability in plants.PLoS genetics · 2025Article
- Hormonomics profiles revealed the mechanisms of cold stratification in breaking the dormancy during seed germination and emergence process of Polygonatum sibiricum Red.Plant signaling & behavior · 2025Article
- Does genetic variation in controlled experiments predict phenology of wild plants?bioRxiv : the preprint server for biology · 2025Article
- From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms.Development (Cambridge, England) · 2025Review
- Stochastic gene expression in auxin signaling in the floral meristem of Arabidopsis thaliana.Nature communications · 2025Article
- Utilizing CRISPR-based genetic modification for precise control of seed dormancy: progress, obstacles, and potential directions.Molecular biology reports · 2025Review
- Hints of Biological Activity of Xerosydryle: Preliminary Evidence on the Early Stages of Seedling Development.International journal of molecular sciences · 2024Article
- Playing the field: The molecular basis of fruit morphology-based bet-hedging.The Plant cell · 2024Article
- A commitment for life: Decades of unraveling the molecular mechanisms behind seed dormancy and germination.The Plant cell · 2024Review
- Bet-hedging and variability in plant development: seed germination and beyond.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Dormancy heterogeneity among Arabidopsis thaliana seeds is linked to individual seed size.Plant communications · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetically identical plants growing in the same conditions can display heterogeneous phenotypes. Here we use Arabidopsis seed germination time as a model system to examine phenotypic variability and its underlying mechanisms. We show extensive variation in seed germination time variability between Arabidopsis accessions and use a multiparent recombinant inbred population to identify two genetic loci involved in this trait. Both loci include genes implicated in modulating abscisic acid (ABA) sensitivity. Mutually antagonistic regulation between ABA, which represses germination, and gibberellic acid (GA), which promotes germination, underlies the decision to germinate and can act as a bistable switch. A simple stochastic model of the ABA-GA network shows that modulating ABA sensitivity can generate the range of germination time distributions we observe experimentally. We validate the model by testing its predictions on the effects of exogenous hormone addition. Our work provides a foundation for understanding the mechanism and functional role of phenotypic variability in germination time.
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