Evidence map›Paper›PMID 34059108›Full record

SynthesisJournal of orthopaedic surgery and research2021

Potential of biomarkers during pharmacological therapy setting for postmenopausal osteoporosis: a systematic review.

Filippo Migliorini, Nicola Maffulli, Filippo Spiezia, Giuseppe Maria Peretti, Markus Tingart, Riccardo Giorgino

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07254429 (Copenhagen Menopause Study), which is not on this map. Cited by 109 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 20 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07254429 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Copenhagen Menopause Study (COMPASS): A Randomized Clinical Trial

TypeinterventionalSponsorMartin Blomberg JensenRan2025 to 2028Enrolled192ConditionsMenopausal Osteoporosis, Bone MarkersArmsTriptorelin 11.25 mg, Sodium Chloride 0.9%, Estradiol (E2), Testosterone, Placebo gel
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 20 syntheses or guidelines pooled it, 136 citations in OpenAlex.

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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Filippo MiglioriniDepartment of Orthopaedic Surgery, University Clinic Aachen, RWTH Aachen University Clinic, Pauwelsstraße 30, 52074, Aachen, Germany. migliorini.md@gmail.com.ORCID http://orcid.org/0000-0001-7220-1221
Nicola MaffulliDepartment of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081, Baronissi, SA, Italy.
Filippo SpieziaDepartment of Orthopedics and Trauma Surgery, Ospedale San Carlo di Potenza, Potenza, Italy.
Giuseppe Maria PerettiDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.
Markus TingartDepartment of Orthopaedic Surgery, University Clinic Aachen, RWTH Aachen University Clinic, Pauwelsstraße 30, 52074, Aachen, Germany.
Riccardo GiorginoDepartment of Orthopaedic Surgery, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
RWTH Aachen University · DEIstituto Ortopedico Galeazzi · ITOspedale San Carlo · ITUniversity of Milan · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiochemical markers of bone turnover (BTMs), such as the bone alkaline phosphatase (bALP), procollagen type I N propeptide (PINP), serum cross-linked C-telopeptides of type I collagen (bCTx), and urinary cross-linked N-telopeptides of type I collagen (NTx), are used to manage therapy monitoring in osteoporotic patients. This systematic review analyzed the potential of these BMTs in predicting the clinical outcomes in terms of BMD, t-score, rate of fractures, and adverse events during the therapy setting in postmenopausal osteoporosis.

methodsAll randomized clinical trials (RCTs) reporting data on biomarkers for postmenopausal osteoporosis were accessed. Only articles reporting quantitative data on the level of biomarkers at baseline and on the outcomes of interest at the last follow-up were eligible.

resultsA total of 36,706 patients were retrieved. Greater values of bALP were associated with a greater rate of vertebral (P = 0.001) and non-vertebral fractures (P = 0.0001). Greater values of NTx at baseline were associated with a greater rate of adverse events at the last follow-up (P = 0.02). Greater values of CTx at baseline were associated with a greater rate of adverse events leading to discontinuation (P = 0.04), gastrointestinal adverse events (P = 0.0001), musculoskeletal adverse events (P = 0.04), and mortality (P = 0.04). Greater values of PINP at baseline were associated with greater rates of gastrointestinal adverse events (P = 0.02) at the last follow-up.

conclusionThe present analysis supports the adoption of BMTs during pharmacological therapy setting of patients suffering from osteoporosis. LEVEL OF EVIDENCE: I, systematic review of RCTs.

Indexed as

AgedAged, 80 and overAlkaline PhosphataseBiomarkersBone DensityBone Density Conservation AgentsCefotaximeCollagen Type IFemaleHumansMiddle AgedMonitoring, PhysiologicOsteoporosis, PostmenopausalPeptide FragmentsPeptidesProcollagenAlkaline PhosphataseALPL protein, humanbenzathine cefotaximeBiomarkersBone Density Conservation AgentsCefotaximeCollagen Type Icollagen type I trimeric cross-linked peptidePeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptidebALPbCTxBiomarkersNTxOsteoporosisPINP

Identifiers

PMID34059108
PMCPMC8165809
OpenAlexW3164134153

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.