ArticleBMC infectious diseases2021
Hematological indices and abnormalities among patients with uncomplicated falciparum malaria in Kosti city of the White Nile state, Sudan: a comparative study.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
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- Recrudescent severe malaria due to Plasmodium falciparum following treatment in a Taiwanese patient: a case report.Malaria journal · 2025Article
- Variations in haematological and inflammatory biomarkers and their association with Plasmodium falciparum malaria: a cross-sectional comparative study at a clinic in Ghana.Malaria journal · 2025Article
- Markers of neutrophil activation and some immune and haematological indices in malaria infection during pregnancy.BMC immunology · 2025Article
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- Intestinal Parasitic Infections and Associated Risk Factors Among Children in an Internally Displaced Center (IDC) in Kosti City of the White Nile State, Sudan.Journal of parasitology research · 2025Article
- Assessment of the selected hematological profiles among malaria andJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Association between asymptomatic Plasmodium falciparum malaria infection, anaemia and mean corpuscular volume of school children in the Volta Region of Ghana.European journal of microbiology & immunology · 2024Article
- The application value of mean red blood cell volume and red blood cell volume distribution width combined with total serum bilirubin in the early screening of neonatal hemolytic disease.BMC pediatrics · 2023Article
- Genome-Wide Association Study on the Hematological Phenotypic Characteristics of the Han Population from Northwest China.Pharmacogenomics and personalized medicine · 2022Article
- Analysis of the relationship between malaria and inflammatory biomarker levels in children in rural Iraq: Impact of nutritional deficiencies, anemia, and hematological disorders.Tropical parasitologyArticle
- Haematological responses in children under 5 years with malaria and soil-transmitted helminth coinfections in Delta State, Nigeria: a cross-sectional study.Therapeutic advances in infectious diseaseArticle
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10 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and abnormalities between Plasmodium falciparum-infected patients and malaria-negative subjects in Kosti city of the White Nile State, Sudan.
methodsA comparative, cross-sectional study was conducted at the Clinical Laboratory Unit of Kosti Teaching Hospital from June to December 2018. A total of 392 participants (192 P. falciparum-infected patients and 200 malaria-negative subjects) were recruited in the study. Hematological indices of hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and platelets were measured, and their median values were statistically compared.
resultsThe majority of P. falciparum-infected patients (67.6%) showed a low-level parasitemia. The median values of Hb concentration, RBC count, mean corpuscular volume (MCV), mean corpuscular Hb (MCH) and mean corpuscular Hb concentration (MCHC) were significantly lower in P. falciparum-infected patients, while the median red cell distribution width (RDW) was significantly higher in the patients compared to malaria-negative subjects. Anemia, low MCV, low MCH, low MCHC and high RDW were significantly associated with falciparum malaria, but parasitemia level was not significantly associated with anemia severity. The median total WBC count was non-significantly higher in P. falciparum-infected patients, with neutropenia being significantly associated with falciparum malaria. The median platelet count was significantly lower in P. falciparum-infected patients, with thrombocytopenia being significantly associated with falciparum malaria.
conclusionsFalciparum malaria among patients in Kosti city of the White Nile State, Sudan is predominantly of low-level parasitemia. It is significantly associated with anemia, low MCV, low MCH, low MCHC, high RDW, thrombocytopenia and neutropenia. However, parasitemia level is not a significant predictor of anemia severity. On the other hand, leucopenia is not useful to predict falciparum malaria. Further large-scale studies in community and healthcare settings and inclusion of patients with complicated or severe malaria and those with high parasite densities are recommended.
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