ArticlePlacenta2021
Placental pathology in COVID-19 affected pregnant women: A prospective case-control study.
Article in Placenta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Risk Factors and Outcomes Associated With Delayed Villous Maturation in Placenta: A Systematic Review and Meta-Analysis.BJOG : an international journal of obstetrics and gynaecology · 2026Pooled it
- Neonatal outcomes among pregnant women with COVID-19: a systematic scoping review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Pooled it
- Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern.Placenta · 2022Pooled it
- Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis.American journal of obstetrics & gynecology MFM · 2021Pooled it
- Altered Endocannabinoid Signaling in Placentas from SARS-CoV-2-Infected Pregnancies.Diagnostics (Basel, Switzerland) · 2026Article
- Maternal Obesity Modifies the Impact of Active SARS-CoV-2 Infection on Placental Pathology.Viruses · 2025Article
- Pregnancy outcomes in women with severe acute respiratory syndrome coronavirus 2 reinfections compared to those with a single infection: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- Impact of COVID-19 disease on placental histopathology. PLAXAVID study.Histology and histopathology · 2024Observational
- Histological Alterations in Placentas of Pregnant Women with SARS-CoV-2 Infection: A Single-Center Case Series.Pathogens (Basel, Switzerland) · 2023Article
- Impact of COVID-19 on Fetal Outcomes in Pregnant Women: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2023Review
- Maternal, Perinatal, and Neonatal Outcomes of COVID-19 Severity in Pregnant Women: A Retrospective Study from Oman.Oman medical journal · 2023Article
- Placental pathology in sudden intrauterine death (SIUD) in SARS-CoV-2-positive oligosymptomatic women.Archives of gynecology and obstetrics · 2023Article
- Immune Response and Transplacental Antibody Transfer in Pregnant Women after COVID-19 Vaccination.Journal of personalized medicine · 2023Article
- Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations.JCI insight · 2023Article
- Article
- Effect of asymptomatic COVID-19 infection on the placenta in the third trimester of pregnancy: A prospective case-control study.Turkish journal of obstetrics and gynecology · 2022Article
- Intrauterine fetal demise as a result of maternal COVID-19 infection in the third trimester of pregnancy: A case report.International journal of surgery case reports · 2022Article
- Histopathological features in advanced abdominal pregnancies co-infected with SARS-CoV-2 and HIV-1 infections: A case evaluation.European journal of obstetrics & gynecology and reproductive biology: X · 2022Article
- Placental Characteristics of a Large Italian Cohort of SARS-CoV-2-Positive Pregnant Women.Microorganisms · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDuring pregnancy, SARS-CoV-2 infection may cause an abnormal development of the placenta, thus influencing maternal and fetal outcomes. Few studies have reported data on placental morphology and histology in infected pregnant patients, although not compared with carefully matched controls. The aim of this study is to compare placental morphology and histology of pregnant women affected by SARS-CoV-2 to non-infected controls.
methodsThis is a prospective multicenter case-control study on 64 pregnant women affected by SARS-CoV-2 who delivered at term or late-preterm. Data were collected about pregnancy course, maternal and fetal outcomes, placental biometry and macro- and microscopical morphology. 64 not-infected women were identified as controls, matched by age, body mass index and ethnicity.
resultsCases and controls had similar fetal and maternal outcomes. No significant differences were observed in placental macro- or microscopical morphology between the two groups. In the cases treated with antivirals, chloroquine, LMWH or antibiotics, placentas were heavier but not more efficient than the non-treated, since the fetal/placental weight ratio did not differ. Moreover, delayed villous maturation was more frequent in treated women, although not significantly. The newborns whose mothers received oxygen therapy as treatment had higher levels of umbilical cord pO₂ at birth. DISCUSSION: In this prospective case-control study, SARS-CoV-2 infection during the third trimester did not influence placental histological pattern. Pharmacological and oxygen therapy administered to women affected by this viral infection could impact maternal and fetal outcomes and be associated to placental histological alterations.
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