Evidence map›Paper›PMID 34058561›Full record

ArticlePsychoneuroendocrinology2021

Risky family climates presage increased cellular aging in young adulthood.

Gene H Brody, Tianyi Yu, Edith Chen, Michael Kobor, Steven R H Beach, Man-Kit Lei, Ashley Barr, David Tse-Shen Lin, Gregory E Miller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Gene H BrodyCenter for Family Research, University of Georgia, 1095 College Station Road, Athens 30602-4527, GA, USA.
Tianyi YuCenter for Family Research, University of Georgia, 1095 College Station Road, Athens 30602-4527, GA, USA.
Edith ChenDepartment of Psychology, Northwestern University, Evanston, IL, USA; Institute for Policy Research, Northwestern University, Evanston, IL, USA.
Michael KoborDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Steven R H BeachCenter for Family Research, University of Georgia, 1095 College Station Road, Athens 30602-4527, GA, USA; Department of Psychology, University of Georgia, Athens, GA, USA.
Man-Kit LeiDepartment of Sociology, University of Georgia, Athens, GA, USA.
Ashley BarrDepartment of Sociology, University of Buffalo, Buffalo, NY, USA.
David Tse-Shen LinBritish Columbia Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Gregory E MillerDepartment of Psychology, Northwestern University, Evanston, IL, USA; Institute for Policy Research, Northwestern University, Evanston, IL, USA.
University of Georgia · USNorthwestern University · USBC Children's Hospital · CAUniversity at Buffalo, State University of New York · USUniversity of British Columbia · CA

Funding

RURAL AFRICAN AMERICAN YOUNG ADULTS' PATHWAYS TO PSYCHOSOCIAL AND PHYSICAL HEALTHR01HD030588 · NICHD · UNIVERSITY OF GEORGIA (UGA) · PI EHRLICH, KATHERINE BABCOCK · 1993 to 2023
$12.0M
Vulnerability to Drug Use & HIV: Advancing Prevention for Rural African AmericansP30DA027827 · NIDA · UNIVERSITY OF GEORGIA · PI BRODY, GENE H. · 2009 to 2018
$10.2M
Research Support CoreP50DA051361 · NIDA · UNIVERSITY OF GEORGIA · PI EHRLICH, KATHERINE BABCOCK · 2020 to 2024
$9.7M
Origin of Chronic Diseases of Aging Among Rural African American Young AdultsR01HD091046 · NICHD · UNIVERSITY OF GEORGIA · PI BRODY, GENE H. · 2018 to 2020
$923k
NICHD NIH HHS R01 HD030588NICHD NIH HHS R01 HD091046NIDA NIH HHS P30 DA027827NIDA NIH HHS P50 DA051361
6 · The paper itself

Abstract

A scientific consensus is emerging that children reared in risky family climates are prone to chronic diseases and premature death later in life. Few prospective data, however, are available to inform the mechanisms of these relationships. In a prospective study involving 323 Black families, we sought to determine whether, and how, childhood risky family climates are linked to a potential risk factor for later-life disease: increases in cellular aging (indexed by epigenetic aging). As hypothesized, risky family climates were associated with greater outflows of the stress hormones epinephrine and norepinephrine at ages 19 and 20 years; this, in turn, led to increases in cellular aging across ages 20-27 years. If sustained, these tendencies may place children from risky family climates on a trajectory toward the chronic diseases of aging.

Indexed as

AgingCellular SenescenceAdultChildChronic DiseaseHumansProspective StudiesRisk FactorsYoung AdultCatecholamineCellular agingRisky family climateYoung adulthood

Identifiers

PMID34058561
PMCPMC8217285
OpenAlexW3163880134

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.