Evidence map›Paper›PMID 34058320›Full record

ArticleJournal of pharmacological and toxicological methods

A stable cell line inducibly expressing hERG1a/1b heteromeric channels.

Erick B Ríos-Pérez, Fang Liu, Whitney A Stevens-Sostre, Catherine A Eichel, Jonathan Silignavong, Gail A Robertson

Open access · greenAbstract read
In one paragraph

Article in Journal of pharmacological and toxicological methods. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. A privileged ER compartment for posttranslational heteromeric assembly of an ion channel.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Erick B Ríos-PérezDept. of Neuroscience and Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave. #5505, Madison, WI 53705, United States of America.
Fang LiuDept. of Neuroscience and Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave. #5505, Madison, WI 53705, United States of America.
Whitney A Stevens-SostreDept. of Neuroscience and Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave. #5505, Madison, WI 53705, United States of America.
Catherine A EichelDept. of Neuroscience and Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave. #5505, Madison, WI 53705, United States of America.
Jonathan SilignavongDept. of Neuroscience and Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave. #5505, Madison, WI 53705, United States of America.
Gail A RobertsonDept. of Neuroscience and Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave. #5505, Madison, WI 53705, United States of America. Electronic address: garobert@wisc.edu.
University of Wisconsin–Madison · US

Funding

Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Translational Control of Cardiac ExcitabilityR01HL131403 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Gail A Robertson · 2016 to 2026
$6.0M
Allosteric Regulation of KCNH ChannelsR01NS081320 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERTSON, GAIL A · 2012 to 2022
$3.4M
NHLBI NIH HHS R01 HL131403NHLBI NIH HHS T32 HL007936NINDS NIH HHS R01 NS081320
6 · The paper itself

Abstract

Heterologously expressed hERG channels represent a mainstay of in vitro drug safety screens intended to mitigate risk of cardiac I

Indexed as

Arrhythmias, CardiacEther-A-Go-Go Potassium ChannelsERG1 Potassium ChannelHEK293 CellsHumansMyocytes, CardiacERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsAction potentialArrhythmiaCiPADrug screeningHeartKCNHKCNH2Kv11.1qNETRepolarization

Identifiers

PMID34058320
PMCPMC8663138
OpenAlexW3164108633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.