ArticlePlant biotechnology journal2021
CTP synthase is essential for early endosperm development by regulating nuclei spacing.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Candidate Gene for Kernel-Related Traits in Maize Revealed by a Combination of GWAS and Meta-QTL Analyses.Plants (Basel, Switzerland) · 2025Article
- Quantitative Proteomic Analysis Deciphers the Molecular Mechanism for Endosperm Nuclear Division in Early Rice Seed Development.Plants (Basel, Switzerland) · 2023Article
- Supplementing the Nuclear-Encoded PSII Subunit D1 Induces Dramatic Metabolic Reprogramming in Flag Leaves during Grain Filling in Rice.Plants (Basel, Switzerland) · 2023Article
- Fine-mapping and candidate gene analysis of the Mcgy1 locus responsible for gynoecy in bitter gourd (Momordica spp.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- GTP-Dependent Regulation of CTP Synthase: Evolving Insights into Allosteric Activation and NHBiomolecules · 2022Review
- Identification and Allele Combination Analysis of Rice Grain Shape-Related Genes by Genome-Wide Association Study.International journal of molecular sciences · 2022Article
- Cytidine Triphosphate Synthase Four FromFrontiers in plant science · 2022Article
- A VIN3-like Protein OsVIL1 Is Involved in Grain Yield and Biomass in Rice.Plants (Basel, Switzerland) · 2021Article
- CTP synthase is essential for early endosperm development by regulating nuclei spacing.Plant biotechnology journal · 2021Article
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cereal grain endosperms are an important source of human nutrition. Nuclear division in early endosperm development plays a major role in determining seed size; however, this development is not well understood. We identified the rice mutant endospermless 2 (enl2), which shows defects in the early stages of endosperm development. These phenotypes arise from mutations in OsCTPS1 that encodes a cytidine triphosphate synthase (CTPS). Both wild-type and mutant endosperms were normal at 8 h after pollination (HAP). In contrast, at 24 HAP, enl2 endosperm had approximately 10-16 clumped nuclei while wild-type nuclei had increased in number and migrated to the endosperm periphery. Staining of microtubules in endosperm at 24 HAP revealed that wild-type nuclei were evenly distributed by microtubules while the enl2-2 nuclei were tightly packed due to their reduction in microtubule association. In addition, OsCTPS1 interacts with tubulins; thus, these observations suggest that OsCTPS1 may be involved in microtubule formation. OsCTPS1 transiently formed macromolecular structures in the endosperm during early developmental stages, further supporting the idea that OsCTPS1 may function as a structural component during endosperm development. Finally, overexpression of OsCTPS1 increased seed weight by promoting endosperm nuclear division, suggesting that this trait could be used to increase grain yield.
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