ReviewJornal brasileiro de nefrologia
A review of Covid-19 and acute kidney injury: from pathophysiology to clinical results.
Review in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 67 citations in OpenAlex.
- Evaluation of muscle strength and renal function in survivors of severe COVID-19: A 12-month follow-up study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Article
- Impact of COVID-19 on Renal Function: Analysis of Acute Kidney Injury Across Three Pandemic Waves.Biomedicines · 2025Article
- Clinical Profiles and Mortality-Associated Risk Factors in Patients with Acute Kidney Injury from Atlixco, Puebla, Mexico.Diagnostics (Basel, Switzerland) · 2025Article
- Acute kidney injury in the pandemic years revisited: distinct patterns of staging and recovery in patients with and without COVID-19.Journal of nephrology · 2025Article
- Investigation of renal function in patients with long COVID in the Amazon region: a cross-sectional study.BMC infectious diseases · 2025Observational
- Survival of critically ill people with COVID-19 and acute kidney injury undergoing hemodialysis in public and private hospitals in Joinville: a cohort study, 2020-2021.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- Article
- ELMO CPAP: an innovative type of ventilatory support for COVID-19-related acute respiratory distress syndrome.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
- Acute renal failure, COVID-19 and deaths, worrying rates in intensive care units: a cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2024Article
- Acute kidney injury in coronavirus disease: a comparative study of the two waves in Brazil.Einstein (Sao Paulo, Brazil) · 2024Article
- Clinical and Epidemiological Characteristics of Patients with COVID-19 Admitted to the Intensive Care Unit: A Two-Year Retrospective Analysis.Life (Basel, Switzerland) · 2023Article
- The Investigation of Kidney Involvement in 430 Hospitalized Patients with Omicron COVID-19 in Tianjin, China.Blood purification · 2023Article
- The Perspective of Vitamin D on suPAR-Related AKI in COVID-19.International journal of molecular sciences · 2022Review
- Rhabdomyolysis-Induced AKI (RIAKI) Including the Role of COVID-19.International journal of molecular sciences · 2022Review
- Influence of early hemodialysis on the septic acute kidney injury outcome.Revista da Escola de Enfermagem da U S P · 2022Observational
- Same disease, different outcomes: a retrospective cohort study of COVID-19-associated AKI across Brazil's dual-tiered healthcare system.Jornal brasileiro de nefrologiaArticle
- COVID-19 and acute or chronic kidney disease: a crescent learning.Jornal brasileiro de nefrologiaArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) in hospitalized patients with COVID-19 is associated with higher mortality and a worse prognosis. Nevertheless, most patients with COVID-19 have mild symptoms, and about 5% can develop more severe symptoms and involve hypovolemia and multiple organ dysfunction syndrome. In a pathophysiological perspective, severe SARS-CoV-2 infection is characterized by numerous dependent pathways triggered by hypercytokinemia, especially IL-6 and TNF-alpha, leading to systemic inflammation, hypercoagulability, and multiple organ dysfunction. Systemic endotheliitis and direct viral tropism to proximal renal tubular cells and podocytes are important pathophysiological mechanisms leading to kidney injury in patients with more critical infection, with a clinical presentation ranging from proteinuria and/or glomerular hematuria to fulminant AKI requiring renal replacement therapies. Glomerulonephritis, rhabdomyolysis, and nephrotoxic drugs are also associated with kidney damage in patients with COVID-19. Thus, AKI and proteinuria are independent risk factors for mortality in patients with SARS-CoV-2 infection. We provide a comprehensive review of the literature emphasizing the impact of acute kidney involvement in the evolutive prognosis and mortality of patients with COVID-19.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.