ArticleIEEE transactions on bio-medical engineering2022
Effective Ultrasonic Stimulation in Human Peripheral Nervous System.
Article in IEEE transactions on bio-medical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A Wearable Dual-Mode Probe for Image-Guided Closed-Loop Ultrasound Neuromodulation.IEEE transactions on biomedical circuits and systems · 2025Article
- Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation.bioRxiv : the preprint server for biology · 2025Article
- Reduction of Anxiety-Related Symptoms Using Low-Intensity Ultrasound Neuromodulation on the Auricular Branch of the Vagus Nerve: Preliminary Study.JMIR neurotechnology · 2025Article
- A Physiological Marker for Deep Brain Ultrasonic Neuromodulation.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
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- Targeted drug release from stable and safe ultrasound-sensitive nanocarriers.Frontiers in molecular biosciences · 2024Article
- Controlled ultrasonic interventions through the human skull.Frontiers in human neuroscience · 2024Article
- Stem cell-derived brain organoids for controlled studies of transcranial neuromodulation.Heliyon · 2023Article
- Remote targeted electrical stimulation.Journal of neural engineering · 2023Article
- Peripheral focused ultrasound stimulation and its applications: From therapeutics to human-computer interaction.Frontiers in neuroscience · 2023Review
- Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel PIEZO2.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Effects of transcranial ultrasound stimulation pulsed at 40 Hz on Aβ plaques and brain rhythms in 5×FAD mice.Translational neurodegeneration · 2021Article
- The relationship between parameters and effects in transcranial ultrasonic stimulation.Brain stimulationReview
- Biophysical effects and neuromodulatory dose of transcranial ultrasonic stimulation.Brain stimulationReview
- Article
- Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation.Brain stimulationArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveLow-intensity ultrasound can stimulate excitable cells in a noninvasive and targeted manner, but which parameters are effective has remained elusive. This question has been difficult to answer because differences in transducers and parameters-frequency in particular-lead to profound differences in the stimulated tissue volumes. The objective of this study is to control for these differences and evaluate which ultrasound parameters are effective in stimulating excitable cells.
methodsHere, we stimulated the human peripheral nervous system using a single transducer operating in a range of frequencies, and matched the stimulated volumes with an acoustic aperture.
resultsWe found that low frequencies (300 kHz) are substantially more effective in generating tactile and nociceptive responses in humans compared to high frequencies (900 kHz). The strong effect of ultrasound frequency was observed for all pressures tested, for continuous and pulsed stimuli, and for tactile and nociceptive responses.
conclusionThis prominent effect may be explained by a mechanical force associated with ultrasound. The effect is not due to heating, which would be weaker at the low frequency. SIGNIFICANCE: This controlled study reveals that ultrasonic stimulation of excitable cells is stronger at lower frequencies, which guides the choice of transducer hardware for effective ultrasonic stimulation of the peripheral nervous system in humans.
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