Evidence map›Paper›PMID 34057794›Full record

ArticleMolecular oncology2021

Homocysteine induces podocyte apoptosis by regulating miR-1929-5p expression through c-Myc, DNMT1 and EZH2.

Lin Xie, Shengchao Ma, Ning Ding, Yanhua Wang, Guanjun Lu, Lingbo Xu, Qingqing Wang, Kun Liu, Yuzheng Jie, Hui Zhang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecular oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Lin XieSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Shengchao MaSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Ning DingSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Yanhua WangSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Guanjun LuNHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, China.
Lingbo XuSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Qingqing WangSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Kun LiuNHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, China.
Yuzheng JieNHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, China.
Hui ZhangSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Anning YangSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Yujing GaoSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Huiping ZhangNHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, China.
Yideng JiangSchool of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.ORCID 0000-0002-4882-5197
Ningxia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a common and complex disease in kidneys which has been associated with an increased risk of renal cell carcinoma. Elevated homocysteine (Hcy) levels are known to influence the development and progression of CKD by regulating podocyte injury and apoptosis. To investigate the molecular mechanisms triggered in podocytes by Hcy, we used cbs

Indexed as

DNA (Cytosine-5-)-Methyltransferase 1Enhancer of Zeste Homolog 2 ProteinHomocysteineMicroRNAsPodocytesProto-Oncogene Proteins c-mycAnimalsApoptosisHumansMiceDNA (Cytosine-5-)-Methyltransferase 1Dnmt1 protein, mouseEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHomocysteineMicroRNAsMIRN1929 microRNA, mouseMyc protein, mouseProto-Oncogene Proteins c-mycc-MycDNMT1EZH2homocysteinekidneymiR-1929-5p

Identifiers

PMID34057794
PMCPMC8564658
OpenAlexW3164326712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.