Evidence map›Paper›PMID 34057681›Full record

ArticleVirologica Sinica2021

Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques.

Chunxiu Wu, Jin Zhao, Ruiting Li, Fengling Feng, Yizi He, Yanjun Li, Runhan Huang, Guangye Li, Heng Yang, Genhong Cheng and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Chunxiu WuState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, 510530, China.
Jin ZhaoSchool of Public Health (Shenzhen), Sun Yat-Sen University, Guangdong, 518107, China.
Ruiting LiSchool of Public Health (Shenzhen), Sun Yat-Sen University, Guangdong, 518107, China.
Fengling FengSchool of Public Health (Shenzhen), Sun Yat-Sen University, Guangdong, 518107, China.
Yizi HeState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, 510530, China.
Yanjun LiSchool of Public Health (Shenzhen), Sun Yat-Sen University, Guangdong, 518107, China.
Runhan HuangSchool of Public Health (Shenzhen), Sun Yat-Sen University, Guangdong, 518107, China.
Guangye LiGuangdong Landau Biotechnology Co. Ltd, Guangzhou, 510700, China.
Heng YangCenter for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Genhong ChengCenter for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.
Ling ChenState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, 510530, China.
Feng MaCenter for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China. maf@ism.pumc.edu.cn.ORCID http://orcid.org/0000-0002-2975-0118
Pingchao LiState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, 510530, China. li_pingchao@gibh.ac.cn.ORCID http://orcid.org/0000-0001-5046-0855
Caijun SunSchool of Public Health (Shenzhen), Sun Yat-Sen University, Guangdong, 518107, China. suncaijun@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-2000-7053
Sun Yat-sen University · CNChinese Academy of Sciences · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholesterol-25-hydroxylase (CH25H) and its enzymatic product 25-hydroxycholesterol (25HC) exert broadly antiviral activity including inhibiting HIV-1 infection. However, their antiviral immunity and therapeutic efficacy in a nonhuman primate model are unknown. Here, we report that the regimen of 25HC combined with antiretroviral therapy (ART), provides profound immunological modulation towards inhibiting viral replication in chronically SIV

Indexed as

HIV InfectionsSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsAntiviral AgentsCD4-Positive T-LymphocytesHydroxycholesterolsMacaca mulatta25-hydroxycholesterolAntiviral AgentsHydroxycholesterols25-hydroxycholesterol (25HC)Antiretroviral therapy (ART)HIVMacaqueSIV

Identifiers

PMID34057681
PMCPMC8165512
OpenAlexW3165365573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.