Evidence map›Paper›PMID 34057644›Full record

ReviewJournal of assisted reproduction and genetics2021

Uterus transplantation: state of the art in 2021.

Elliott G Richards, Ruth M Farrell, Stephanie Ricci, Uma Perni, Cristiano Quintini, Andreas Tzakis, Tommaso Falcone

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Anesthesia for uterine transplantation.Anesthesia and pain medicine · 2026
    Review
  3. Risks of uterus transplantation: a scoping review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026
    Article
  4. New Frontiers in Reproductive Health: Australians' Support for Uterus Transplantation.The Australian & New Zealand journal of obstetrics & gynaecology · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Tissue Engineering in Gynecology.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Primary Amenorrhea and Differences of Sex Development.Seminars in reproductive medicine · 2022
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elliott G RichardsObstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Desk A-81, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.ORCID http://orcid.org/0000-0002-7364-8604
Ruth M FarrellObstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Desk A-81, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Stephanie RicciObstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Desk A-81, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Uma PerniObstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Desk A-81, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Cristiano QuintiniDigestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Andreas TzakisDigestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Tommaso FalconeObstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Desk A-81, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. falcont@ccf.org.
Cleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo provide a comprehensive review of uterus transplantation in 2021, including a discussion of pregnancy outcomes of all reported births to date, the donor and recipient selection process, the organ procurement and transplant surgeries, reported complications, postoperative monitoring, preimplantation preparation, and ethical considerations.

methodsLiterature review and expert commentary.

resultsReports of thirty-one live births following uterus transplantation have been published from both living and deceased donors. The proper selection of donors and recipients is a labor-intensive process that requires advanced planning. A multidisciplinary team is critical. Reported complications in the recipient include thrombosis, infection, vaginal stricture, antenatal complications, and graft failure. Graft rejection is a common occurrence but rarely leads to graft removal. While most embryo transfers are successful, recurrent implantation failures in uterus transplant patients have been reported. Rates of preterm delivery are high but appear to be declining; more data, including long-term outcome data, is needed.

conclusionsUterus transplantation is an emerging therapy for absolute uterine factor infertility, a condition previously without direct treatment options. It is paramount that reproductive health care providers are familiar with the uterus transplantation process as more patients seek and receive this treatment.

Indexed as

Live BirthReproductive Techniques, AssistedFemaleHumansInfertility, FemalePregnancyPregnancy OutcomeUterusMullerian agenesisReproductive surgeryUterine factor infertilityUterus transplantation

Identifiers

PMID34057644
PMCPMC8490545
OpenAlexW3164695648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.