Trial reportGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2021
Barriers to successful dichoptic treatment for amblyopia in young children.
Trial report in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Binocular treatment for amblyopia: a systematic review.International ophthalmology · 2024Pooled it
- Randomised trial of three treatments for amblyopia: Vision therapy and patching, perceptual learning and patching alone.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Trial
- Trial
- Advances in behavioral vision training for the treatment of childhood amblyopia: a narrative review.Translational pediatrics · 2026Review
- Binocular Vision Anomalies: An Update on Prevalence, Impact, Technological and Treatment Developments and Current Challenges.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Review
- Systematic Review and Meta-Analysis of RCTs on Efficacy of Conventional vs. Emerging Treatments for Amblyopia.Life (Basel, Switzerland) · 2026Review
- Effectiveness of Active Vision Therapy in Children with Bilateral Refractive Amblyopia.Journal of ophthalmic & vision research · 2026Article
- An Eye Movement Monitoring Tool: Towards a Non-Invasive Device for Amblyopia Treatment.Sensors (Basel, Switzerland) · 2025Article
- Evolving Strategies in Amblyopia Management: From Traditional Therapies to Cutting-Edge Innovations.Cureus · 2025Review
- Visual Performance of Children with Amblyopia after 6 Weeks of Home-Based Dichoptic Visual Training.Children (Basel, Switzerland) · 2024Article
- Current Developments in the Management of Amblyopia with the Use of Perceptual Learning Techniques.Medicina (Kaunas, Lithuania) · 2023Review
- Stereoptic serious games as a visual rehabilitation tool for individuals with a residual amblyopia (AMBER trial): a protocol for a crossover randomized controlled trial.BMC ophthalmology · 2023Article
- Applications and implications for extended reality to improve binocular vision and stereopsis.Journal of vision · 2023Article
- Evaluation of the Efficacy of a New Dichoptic Digital Platform to Treat the Anisometropic and Isometropic Amblyopia.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn an ongoing randomised clinical trial comparing dichoptic VR video games with patching for amblyopia, we evaluated any potential barriers to successful use of this novel amblyopia treatment method.
methodsFrom December 2017, all newly diagnosed amblyopic children were recruited. Excluded were children under age 4 and patients with strabismus exceeding 30PD. The video game was played for 1 h per week at the outpatient clinic under direct supervision. Records were kept of difficulties encountered during treatment and categorised into domains. Factors influencing the successful completion of this treatment were identified and related to patient characteristics.
resultsNinety-one children were recruited for the trial, 20 parents refused participation before randomisation, because of the logistical challenges the outpatient dichoptic treatment would cause them. Of the 17 children who commenced dichoptic treatment (median age 6.2 years; IQR 4.9-8.4 years), 10 did not complete treatment. Children under age 5.5 years were unable to comprehend the game settings or the game itself. Older children (N = 7; 41%) were less willing to comply with the video game. Loss of interest in the game (N = 8; 47%) was found to be a limiting factor at all ages.
conclusionHalf of the children failed to complete VR dichoptic treatment, mainly due to young age. In countries with nationwide screening where amblyopia is detected before age 6, the applicability of such dichoptic treatment is limited.
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