Evidence map›Paper›PMID 34057471›Full record

ArticleNeuro-oncology2021

Dramatic response of STRN-NTRK-fused malignant glioneuronal tumor to larotrectinib in adult.

Julie Boyer, Cristina Birzu, Franck Bielle, Clara Goulas, Julien Savatovsky, Carine Karachi, Ahmed Idbaih

Abstract readLetter
In one paragraph

Article in Neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. JCO precision oncology · 2026
    Review
  3. Adult Low-Grade Glioma WithCase reports in pathology · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Case Report: A novelFrontiers in oncology · 2022
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julie BoyerInserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Service de Neurologie 2-Mazarin, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Sorbonne Université, F-75013, Paris, France.
Cristina BirzuInserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Service de Neurologie 2-Mazarin, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Sorbonne Université, F-75013, Paris, France.
Franck BielleInserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Service de Neuropathologie-Escourolle, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Sorbonne Université, F-75013, Paris, France.ORCID 0000-0001-6564-6388
Clara GoulasService de Pharmacie, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, F-75013, Paris, France.
Julien SavatovskyService d'Imagerie Médicale, Hôpital Fondation Rothschild, F-75019, Paris, France.
Carine KarachiInserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Service de Neurochirurgie, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Sorbonne Université, F-75013, Paris, France.
Ahmed IdbaihInserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Service de Neurologie 2-Mazarin, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Sorbonne Université, F-75013, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

NeoplasmsPyrimidinesAdultCalmodulin-Binding ProteinsHumansMembrane ProteinsNerve Tissue ProteinsOncogene Proteins, FusionProtein Kinase InhibitorsPyrazolesCalmodulin-Binding ProteinslarotrectinibMembrane ProteinsNerve Tissue ProteinsOncogene Proteins, FusionProtein Kinase InhibitorsPyrazolesPyrimidinesSTRN protein, humanglioneuronal tumormolecular targeted therapyNTRK fusion

Identifiers

PMID34057471
PMCPMC8248836

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.