Evidence map›Paper›PMID 34057092›Full record

ReviewJournal of Alzheimer's disease : JAD2021

Benson's Disease or Posterior Cortical Atrophy, Revisited.

Oleg Yerstein, Leila Parand, Li-Jung Liang, Adrienne Isaac, Mario F Mendez

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Late-onset diplopia: an unusual presentation of posterior cortical atrophy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Oleg YersteinDepartment of Neurology, Lahey Hospital and Medical Center, Burlington, MA, USA.
Leila ParandDepartment of Neurology, Behavioral Sciences, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Li-Jung LiangDepartment of Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Adrienne IsaacDepartment of Linguistics, Georgetown University, Washington, DC, USA.
Mario F MendezDepartment of Neurology, Behavioral Sciences, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.

Funding

Early-Onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural NetworksRF1AG050967 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MENDEZ, MARIO F. · 2016 to 2016
$1.9M
NIA NIH HHS RF1 AG050967
6 · The paper itself

Abstract

backgroundD. Frank Benson and colleagues first described the clinical and neuropathological features of posterior cortical atrophy (PCA) from patients in the UCLA Neurobehavior Program.

objectiveWe reviewed the Program's subsequent clinical experience with PCA, and its potential for clarifying this relatively rare syndrome in comparison to the accumulated literature on PCA.

methodsUsing the original criteria derived from this clinic, 65 patients with neuroimaging-supported PCA were diagnosed between 1995 and 2020.

resultsOn presentation, most had visual localization complaints and related visuospatial symptoms, but nearly half had memory complaints followed by symptoms of depression. Neurobehavioral testing showed predominant difficulty with visuospatial constructions, Gerstmann's syndrome, and Balint's syndrome, but also impaired memory and naming. On retrospective application of the current Consensus Criteria for PCA, 59 (91%) met PCA criteria with a modification allowing for "significantly greater visuospatial over memory and naming deficits." There were 37 deaths (56.9%) with the median overall survival of 10.3 years (95% CI: 9.6-13.6 years), consistent with a slow neurodegenerative disorder in most patients.

conclusionTogether, these findings recommend modifying the PCA criteria for "relatively spared" memory, language, and behavior to include secondary memory and naming difficulty and depression, with increased emphasis on the presence of Gerstmann's and Balint's syndromes.

Indexed as

AgnosiaOccipital LobeParietal LobeAlzheimer DiseaseAtrophyBiomarkersDiagnosis, DifferentialFemaleGerstmann SyndromeHumansMaleMiddle AgedNeuroimagingNeuropsychological TestsBiomarkersAlzheimer’s diseasebalint’s syndromegerstmann’s syndromeposterior cortical atrophy

Identifiers

PMID34057092
PMCPMC8316293

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.