Evidence map›Paper›PMID 34056992›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-

Nawaf A Alsaif, Mohammed S Taghour, Mohammed M Alanazi, Ahmad J Obaidullah, Abdulrahman A Al-Mehizia, Manal M Alanazi, Saleh Aldawas, Alaa Elwan, Hazem Elkady

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 61 citations in OpenAlex.

  1. Synthesis and Biological Activity of Azolo[Molecules (Basel, Switzerland) · 2026
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  19. Design, synthesis and molecular docking of new fused 1Journal of enzyme inhibition and medicinal chemistry · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Nawaf A AlsaifDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0001-9215-1380
Mohammed S TaghourPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0630-709X
Mohammed M AlanaziDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-0483-8113
Ahmad J ObaidullahDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-7532-6318
Abdulrahman A Al-MehiziaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0001-8711-3873
Manal M AlanaziDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Saleh AldawasDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alaa ElwanPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-4270-616X
Hazem ElkadyPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-0893-6703
King Saud University · SAAl-Azhar University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, a new wave of bis([1, 2, 4]triazolo)[4,3-

Indexed as

Drug DiscoveryAntineoplastic AgentsApoptosisCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureProtein Kinase InhibitorsQuinoxalinesStructure-Activity RelationshipVascular Endothelial Growth Factor Receptor-2Antineoplastic AgentsKDR protein, humanProtein Kinase InhibitorsQuinoxalinesVascular Endothelial Growth Factor Receptor-2Anticancerapoptosisbis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxalinemolecular dockingVEGFR-2

Identifiers

PMID34056992
PMCPMC8168755
OpenAlexW3163986876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.