ArticleBrain and behavior2021
The differential diagnostic value of a battery of oculomotor evaluation in Parkinson's Disease and Multiple System Atrophy.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Vestibular Dysfunction in Parkinson's Disease: A Systematic Review of Signs and Symptoms.Movement disorders clinical practice · 2026Pooled it
- Naturalistic Eye Movement Tasks in Parkinson's Disease: A Systematic Review.Journal of Parkinson's disease · 2024Pooled it
- VR-based quantitative oculomotor analysis and association with regional brain atrophy in MSA.Journal of Parkinson's disease · 2026Article
- Eye tracking as a digital biomarker in neurodegenerative diseases.Journal of neurology · 2026Review
- EYE movement abnormalities in Parkinson's disease: optometric screening and rehabilitation.Clinical parkinsonism & related disorders · 2026Review
- Automated eye-tracking for Parkinson's disease diagnosis: a proof-of-concept cascade classifier study.Clinical parkinsonism & related disorders · 2026Article
- Multiple inflammatory cytokines correlate with the vestibular and oculomotor dysfunction in Fabry disease: a prospective, longitudinal study.Frontiers in immunology · 2026Observational
- The vestibular and oculomotor dysfunction in Fabry disease: a cohort study in China.Annals of medicine · 2025Article
- Follow-up observation of eye movements in multiple system atrophy and Parkinson's disease: a cohort study.BMJ open · 2025Article
- Clinical value of video oculomotor evaluation in the differential diagnosis of multiple system atrophy and Parkinson's disease.Brain and behavior · 2024Article
- Smooth Pursuit and Reflexive Saccade in Discriminating Multiple-System Atrophy With Predominant Parkinsonism From Parkinson's Disease.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Abnormal Ocular Movement in the Early Stage of Multiple-System Atrophy With Predominant Parkinsonism Distinct From Parkinson's Disease.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Loss of torsional quick eye movements during head roll in progressive supranuclear palsy: a new diagnostic marker.Journal of neurology · 2023Article
- Monitoring Eye Movement in Patients with Parkinson's Disease: What Can It Tell Us?Eye and brain · 2023Review
- A novel tablet-based software for the acquisition and analysis of gaze and eye movement parameters: a preliminary validation study in Parkinson's disease.Frontiers in neurology · 2023Article
- Response times for reflexive saccades correlate with cognition in parkinson's disease, not disease severity or duration.Frontiers in neurology · 2022Article
- The differential diagnostic value of a battery of oculomotor evaluation in Parkinson's Disease and Multiple System Atrophy.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
introductionClinical diagnosis of Parkinsonism is still challenging, and the diagnostic biomarkers of Multiple System Atrophy (MSA) are scarce. This study aimed to investigate the diagnostic value of the combined eye movement tests in patients with Parkinson's disease (PD) and those with MSA.
methodsWe enrolled 96 PD patients, 33 MSA patients (18 with MSA-P and 15 with MSA-C), and 40 healthy controls who had their horizontal ocular movements measured. The multiple-step pattern of memory-guided saccade (MGS), the hypometria/hypermetria of the reflexive saccade, the abnormal saccade in smooth pursuit movement (SPM), gaze-evoked nystagmus, and square-wave jerks in gaze-holding test were qualitatively analyzed. The reflexive saccadic parameters and gain of SPM were also quantitatively analyzed.
resultsThe MGS test showed that patients with either diagnosis had a significantly higher incidence of multiple-step pattern compared with controls (68.6%, 65.2%, and versus. 2.5%, p < .05, in PD, MSA, versus. controls, respectively). The reflexive saccade test showed that MSA patients showing a prominent higher incidence of the abnormal saccade (63.6%, both hypometria and hypermetria) than that of PD patients and controls (33.3%, 7.5%, respectively, hypometria) (p < .05). The SPM test showed PD patients had mildly decreased gain among whom 28.1% presenting "saccade intrusions"; and that MSA patients had the significant decreased gain with 51.5% presenting "catch-up saccades"(p < .05). Only MSA patients showed gaze-evoked nystagmus (24.2%), square-wave jerks (6.1%) in gaze-holding test (p < .05).
conclusionsA panel of eye movements tests may help to differentiate PD from MSA. The combined presence of hypometria and hypermetria in saccadic eye movement, the impaired gain of smooth pursuit movement with "catch-up saccades," gaze-evoked nystagmus, square-wave jerks in gaze-holding test, and multiple-step pattern in MGS may provide clues to the diagnosis of MSA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.