Evidence map›Paper›PMID 34056691›Full record

ArticleJournal of molecular neuroscience : MN2021

Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF-β/SMAD-2-Dependent Signaling Pathway in Diabetic Rats.

Rashmi Rajput, Vishal Chavda, Snehal S Patel, George E Barreto, Ghulam Md Ashraf

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 4 countries.

Rashmi RajputDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Ahmadabad, Gujarat, 382 481, India.
Vishal ChavdaDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Ahmadabad, Gujarat, 382 481, India.
Snehal S PatelDepartment of Pharmacology, Institute of Pharmacy, Nirma University, Ahmadabad, Gujarat, 382 481, India. snehalpharma53@gmail.com.ORCID http://orcid.org/0000-0002-5002-7530
George E BarretoDepartment of Biological Sciences, University of Limerick, Limerick, Ireland.
Ghulam Md AshrafKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Nirma University · INKing Abdulaziz University · SAUniversity of Limerick · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium overload and hyperglycemia are risks of stroke onset in diabetics. Our study was designed to elucidate the beneficial role of calcium channel blockers by targeting voltage-gated calcium channels in diabetes-associated cerebrovascular complications. Diabetes was induced using the neonatal streptozotocin rat model. After confirmation of diabetes, middle cerebral artery occlusion (MCAO) was carried out. The pre-treatment with 1 mg/kg/day efonidipine was administered for the period of 4 weeks. After 24 h of ischemic induction surgery, the neurological score was determined, and blood was collected for determination of biochemical parameters. Treatment with efonidipine showed a significant reduction in post-ischemic brain infract volume, brain hemisphere weight difference, neurological score, Na

Indexed as

AcetylcholinesteraseAnimalsBrainCalcium Channel BlockersDiabetes Mellitus, ExperimentalDihydropyridinesInfarction, Middle Cerebral ArteryMaleMalondialdehydeNeuroprotective AgentsNitritesNitrophenolsOrganophosphorus CompoundsOxidative StressRatsRats, Sprague-DawleyAcetylcholinesteraseCalcium Channel BlockersDihydropyridinesefonidipineMalondialdehydeNeuroprotective AgentsNitritesNitrophenolsOrganophosphorus CompoundsSmad2 ProteinSmad2 protein, ratTransforming Growth Factor betaVascular Endothelial Growth Factor ACalcium channel blockerCerebroprotectiveEfonidipineMiddle cerebral artery occlusionStroke

Identifiers

PMID34056691
OpenAlexW3164384615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.