Evidence map›Paper›PMID 34056688›Full record

ReviewCurrent allergy and asthma reports2021

Allergens from Edible Insects: Cross-reactivity and Effects of Processing.

Laura De Marchi, Andrea Wangorsch, Gianni Zoccatelli

Abstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Safety of frozen paste from blanched, whole migratory locust (EFSA journal. European Food Safety Authority · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Feasibility of UsingFoods (Basel, Switzerland) · 2025
    Review
  10. Fermentation of House Crickets (Foods (Basel, Switzerland) · 2025
    Review
  11. Observational
  12. Review
  13. Review
  14. House Cricket (Nutrients · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. [Novel foods-What must be considered?]Dermatologie (Heidelberg, Germany) · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laura De MarchiDepartment of Biotechnology, University of Verona, Verona, Italy.
Andrea WangorschMolecular Allergology, Paul-Ehrlich-Institut, Langen, Germany.
Gianni ZoccatelliDepartment of Biotechnology, University of Verona, Verona, Italy. gianni.zoccatelli@univr.it.ORCID 0000-0001-9198-5252

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe recent introduction of edible insects in Western countries has raised concerns about their safety in terms of allergenic reactions. The characterization of insect allergens, the sensitization and cross-reactivity mechanisms, and the effects of food processing represent crucial information for risk assessment. RECENT

findingsAllergic reactions to different insects and cross-reactivity with crustacean and inhalant allergens have been described, with the identification of new IgE-binding proteins besides well-known pan-allergens. Depending on the route of sensitization, different potential allergens seem to be involved. Food processing may affect the solubility and the immunoreactivity of insect allergens, with results depending on species and type of proteins. Chemical/enzymatic hydrolysis, in some cases, abolishes immunoreactivity. More studies based on subjects with a confirmed insect allergy are necessary to identify major and minor allergens and the role of the route of sensitization. The effects of processing need to be further investigated to assess the risk associated with the ingestion of insect-containing food products.

Indexed as

Food HandlingFood HypersensitivityAllergensAnimalsArthropodsCross ReactionsEdible InsectsHumansImmunoglobulin EAllergensImmunoglobulin EArginine kinaseCross-reactivityEdible insectsFood allergyFood processingTropomyosin

Identifiers

PMID34056688
PMCPMC8165055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.