ArticleRice (New York, N.Y.)2021
Xa7, a Small Orphan Gene Harboring Promoter Trap for AvrXa7, Leads to the Durable Resistance to Xanthomonas oryzae Pv. oryzae.
Article in Rice (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- A transmembrane protein confers the Yr26/Yr24/YrCH42/YrG22-mediated stripe rust resistance in wheat.Nature communications · 2026Article
- Effector Triggered Susceptibility and Immunity in Bacterial Diseases of Leaf Blight and Streak in Rice.Rice (New York, N.Y.) · 2026Review
- Molecular Insights into Rice Immunity: Unveiling Mechanisms and Innovative Approaches to Combat Major Pathogens.Plants (Basel, Switzerland) · 2025Review
- Functional innovation through new genes as a general evolutionary process.Nature genetics · 2025Review
- The Role of Genetic Resistance in Rice Disease Management.International journal of molecular sciences · 2025Review
- Use of CRISPR Technology in Gene Editing for Tolerance to Biotic Factors in Plants: A Systematic Review.Current issues in molecular biology · 2024Review
- Orphan geneHorticulture research · 2024Article
- Disease resistance features of the executorFrontiers in plant science · 2024Article
- Chinese cabbage orphan geneFrontiers in plant science · 2024Article
- The Lost and Found: Unraveling the Functions of Orphan Genes.Journal of developmental biology · 2023Review
- Article
- Available cloned genes and markers for genetic improvement of biotic stress resistance in rice.Frontiers in plant science · 2023Review
- TALE-induced cell death executors: an origin outside immunity?Trends in plant science · 2022Review
- TALEs as double-edged swords in plant-pathogen interactions: Progress, challenges, and perspectives.Plant communications · 2022Review
- Plant Executor Genes.International journal of molecular sciences · 2022Review
- Research Advances and Prospects of Orphan Genes in Plants.Frontiers in plant science · 2022Review
- Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe rice (Oryza sativa) gene Xa7 has been hypothesized to be a typical executor resistance gene against Xanthomonas oryzae pv. oryzae (Xoo), and has conferred durable resistance in the field for decades. Its identity and the molecular mechanisms underlying this resistance remain elusive.
resultsHere, we filled in gaps of genome in Xa7 mapping locus via BAC library construction, revealing the presence of a 100-kb non-collinear sequence in the line IRBB7 compared with Nipponbare reference genomes. Complementary transformation with sequentially overlapping subclones of the BACs demonstrated that Xa7 is an orphan gene, encoding a small novel protein distinct from any other resistance proteins reported. A 27-bp effector binding element (EBE) in the Xa7 promoter is essential for AvrXa7-inducing expression model. XA7 is anchored in the endoplasmic reticulum membrane and triggers programmed cell death in rice and tobacco (Nicotiana benthamiana). The Xa7 gene is absent in most cultivars, landraces, and wild rice accessions, but highly homologs of XA7 were identified in Leersia perrieri, the nearest outgroup of the genus Oryza.
conclusionsXa7 acts as a trap to perceive AvrXa7 via EBE
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.