Evidence map›Paper›PMID 34056625›Full record

ArticleCurrent research in neurobiology2021

The transcriptional repressor Rev-erbα regulates circadian expression of the astrocyte Fabp7 mRNA.

William M Vanderheyden, Bin Fang, Carlos C Flores, Jennifer Jager, Jason R Gerstner

Open access · goldAbstract read
In one paragraph

Article in Current research in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. AstrocytePNAS nexus · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

William M VanderheydenElson S. Floyd College of Medicine, Washington State University, Spokane, WA. 99202, USA.
Bin FangGenomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Dr, San Diego, CA 92121.
Carlos C FloresElson S. Floyd College of Medicine, Washington State University, Spokane, WA. 99202, USA.
Jennifer JagerUniversité Côte d'Azur, INSERM, Centre Méditerranéen de Médecine Moléculaire (C3M), Cellular and Molecular Physiopathology of Obesity, Nice, France.
Jason R GerstnerElson S. Floyd College of Medicine, Washington State University, Spokane, WA. 99202, USA.
Centre Méditerranéen de Médecine Moléculaire · FRGenomics Institute of the Novartis Research Foundation · USGeorgia Highlands College · USGleason (United States) · USWashington State University Spokane · US

Funding

Characterizing evolutionarily conserved mechanisms underlying sleep, clocks, and memoryR35GM133440 · NIGMS · WASHINGTON STATE UNIVERSITY · PI GERSTNER, JASON ROBERT · 2019 to 2023
$2.3M
NIGMS NIH HHS R35 GM133440
6 · The paper itself

Abstract

The astrocyte brain-type fatty-acid binding protein (Fabp7) circadian gene expression is synchronized in the same temporal phase throughout mammalian brain. Cellular and molecular mechanisms that contribute to this coordinated expression are not completely understood, but likely involve the nuclear receptor Rev-erbα (NR1D1), a transcriptional repressor. We performed ChIP-seq on ventral tegmental area (VTA) and identified gene targets of Rev-erbα, including

Indexed as

B-FABPBLBPclockglialipidmetabolism

Identifiers

PMID34056625
PMCPMC8162199
OpenAlexW3137829290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.