ArticleNeuro-oncology advances
Hypermetabolism and impaired cerebrovascular reactivity beyond the standard MRI-identified tumor border indicate diffuse glioma extended tissue infiltration.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Toward uncertainty-aware manual delineation of brain tumours using eye-tracking and image-derived features.Physics and imaging in radiation oncology · 2026Article
- Cerebrovascular Reactivity Assessment with Breath-Hold Functional MRI in Patients with Moyamoya Angiopathy: Which Time Period to Analyze?Diagnostics (Basel, Switzerland) · 2026Article
- Frequency-specific resting state fMRI features in gliomas.Journal of neuro-oncology · 2026Article
- Neurovascular coupling and cerebrovascular reactivity: physiology, lifespan development, pathophysiology, and clinical relevance.Frontiers in physiology · 2026Review
- Blood-oxygenation-level-dependent (BOLD) MRI responses to COMagnetic resonance imaging · 2025Article
- Cerebrovascular Reactivity Mapping in Brain Tumors Based on a Breath-Hold Task Using Arterial Spin Labeling.NMR in biomedicine · 2025Article
- Cerebrovascular Reactivity Assessed by Breath-Hold Functional MRI in Patients with Neurological Post-COVID-19 Syndrome-A Pilot Study.Neurology international · 2024Article
- Transient deoxyhemoglobin formation as a contrast for perfusion MRI studies in patients with brain tumors: a feasibility study.Frontiers in physiology · 2024Article
- The peritumoral brain zone in glioblastoma: a review of the pretreatment approach.Polish journal of radiology · 2024Review
- Hemodynamic imaging parameters in brain metastases patients - Agreement between multi-delay ASL and hypercapnic BOLD.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Article
- Evaluation of Gliomas with Magnetic Resonance Fingerprinting with PET Correlation-A Comparative Study.Cancers · 2023Article
- Delineation of recurrent glioblastoma by whole brain spectroscopic magnetic resonance imaging.Radiation oncology (London, England) · 2023Article
- The peritumoral brain zone in glioblastoma: where we are and where we are going.Journal of neuroscience research · 2023Review
- Artificial intelligence-based locoregional markers of brain peritumoral microenvironment.Scientific reports · 2023Article
- Hemodynamic Imaging in Cerebral Diffuse Glioma-Part A: Concept, Differential Diagnosis and Tumor Grading.Cancers · 2022Review
- Review
- Feasibility of glioblastoma tissue response mapping with physiologic BOLD imaging using precise oxygen and carbon dioxide challenge.Magma (New York, N.Y.) · 2022Article
- MRI-defined patterns of infiltration and outcome in patients with glioblastoma.Neuro-oncology advancesArticle
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Authors and funding
8 authors.
Funding
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Abstract
backgroundDiffuse gliomas exhibit diffuse infiltrative growth, often beyond the magnetic resonance imaging (MRI)-detectable tumor lesion. Within this lesion, hypermetabolism and impaired cerebrovascular reactivity (CVR) are found, but its exact distribution pattern into the peritumoral environment is unknown. Our aim was to better characterize the extent of diffuse glioma tissue infiltration, beyond the visible lesion (ie, beyond the T1-contrast-enhancing lesion and/or T2/FLAIR-defined tumor border), with metabolic positron emission tomography (PET), and functional MRI CVR (blood oxygenation-level-dependent CVR [BOLD-CVR]) mapping.
methodsFrom a prospective glioma database, 18 subjects (19 datasets) with diffuse glioma (
resultsPatients with diffuse glioma exhibit impaired BOLD-CVR 12 mm beyond the tumor lesion (
conclusionWe demonstrate hypermetabolism and impaired CVR beyond the standard MRI-defined tumor border, suggesting active tumor infiltration in the peritumoral environment.
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