Evidence map›Paper›PMID 34056124›Full record

ArticleRomanian journal of anaesthesia and intensive care2020

Ketamine Versus Tramadol As an Adjunct To PCA Morphine for Postoperative Analgesia After Major Upper Abdominal Surgery: a Prospective, Comparative, Randomized Trial.

Paraskevi K Matsota, Ioanna C Koukopoulou, Konstantinos A Kalimeris, Aikaterini C Kyttari, Kalliopi H Drachtidi, Georgia G Kostopanagiotou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Romanian journal of anaesthesia and intensive care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Paraskevi K Matsota2nd Department of Anaesthesiology, School of Medicine, National and Kapodistrian, University of Athens, "Attikon" University Hospital, Rimini 1 Str, Chaidari, Postal Code 12462, Athens, Greece.
Ioanna C Koukopoulou2nd Department of Anaesthesiology, School of Medicine, National and Kapodistrian, University of Athens, "Attikon" University Hospital, Rimini 1 Str, Chaidari, Postal Code 12462, Athens, Greece.
Konstantinos A Kalimeris2nd Department of Anaesthesiology, School of Medicine, National and Kapodistrian, University of Athens, "Attikon" University Hospital, Rimini 1 Str, Chaidari, Postal Code 12462, Athens, Greece.
Aikaterini C Kyttari2nd Department of Anaesthesiology, School of Medicine, National and Kapodistrian, University of Athens, "Attikon" University Hospital, Rimini 1 Str, Chaidari, Postal Code 12462, Athens, Greece.
Kalliopi H Drachtidi2nd Department of Anaesthesiology, School of Medicine, National and Kapodistrian, University of Athens, "Attikon" University Hospital, Rimini 1 Str, Chaidari, Postal Code 12462, Athens, Greece.
Georgia G Kostopanagiotou2nd Department of Anaesthesiology, School of Medicine, National and Kapodistrian, University of Athens, "Attikon" University Hospital, Rimini 1 Str, Chaidari, Postal Code 12462, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPatient-controlled analgesia (PCA) with morphine is commonly used to provide analgesia following major surgery, but is not sufficient as a monotherapy strategy. This study aimed to compare the adjunctive analgesic effect of ketamine versus tramadol on postoperative analgesia provided via PCA-morphine in patients undergoing major upper abdominal surgeries.

methodsForty-two patients undergoing elective major upper abdominal surgery under general anesthesia were allocated to receive either ketamine (load dose of 0.5 mg kg

resultsThere were no significant differences in patient demographic and intraoperative data between the two groups. Tramadol group had significantly less total morphine consumption during the first 48 postoperative hours (28.905 [16.504] vs 54.524 [20.846] mg [p < 0.001]) and presented significantly lower VAS scores at rest and mobilization (p < 0.05) than the ketamine group. No statistical difference was recorded between the two groups (p > 0.05) regarding postoperative cough, sedation, hallucinations, pruritus, urine retention, and postoperative nausea and vomiting. However, patients in the ketamine group reported dry mouth more frequently than patients in the tramadol group (p = 0.032).

conclusionsPostoperative administration of tramadol was superior to ketamine due to significantly reduced opioid consumption and better pain scores in patients receiving PCA-morphine after major upper abdominal surgery.

Indexed as

Ketaminemorphinepostoperative analgesiatramadol

Identifiers

PMID34056124
PMCPMC8158303
OpenAlexW3165719080

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.