Evidence map›Paper›PMID 34055985›Full record

ArticleBioMed research international2021

Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4.

Jianping Guo, Lei Yin, Xuezhong Zhang, Peng Su, Qiaoli Zhai

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jianping GuoDepartment of Oncology, Maternal and Child Health Care Hospital of Zibo, Zibo 255029, China.
Lei YinHuman Resources Department, Zibo Central Hospital, Zibo 255036, China.
Xuezhong ZhangDepartment of Laboratory Medicine, Zibo Central Hospital, Zibo 255036, China.
Peng SuDepartment of Laboratory Medicine, Zibo Central Hospital, Zibo 255036, China.
Qiaoli ZhaiCenter of Translational Medicine, Zibo Central Hospital, Zibo 255036, China.ORCID https://orcid.org/0000-0002-5570-6604
Central Hospital of Zibo · CNThe Fourth People's Hospital of Zibo City · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteosarcoma is the most common type of bone malignancy, and the pathogenesis has not been entirely elucidated yet. An important deimination modification enzyme PADI4 (peptidylarginine deiminase 4) has attracted much attention in recent years for its important function in several kinds of human tumors. However, the role of PADI4 on osteosarcoma tumorigenesis remains largely unrevealed. Here, we first assessed the effect of PADI4 on osteosarcoma proliferation by the CCK8 method and colony formation assay. Ectopically expressing PADI4 positively regulates the colony formation capacity of both U2OS and Saos-2 cells. Furthermore, we explored the related mechanism and showed that PADI4 could stimulate Wnt/

Indexed as

AdolescentAdultAgedAnimalsbeta CateninBone NeoplasmsCarcinogenesisCell Line, TumorCell ProliferationCholecystokininFemaleHumansMaleMiceMice, NudeMiddle Agedbeta CateninCholecystokinincholecystokinin 9CTNNB1 protein, mousePADI4 protein, humanPadi4 protein, mousePeptide FragmentsProtein-Arginine DeiminasesProtein-Arginine Deiminase Type 4

Identifiers

PMID34055985
PMCPMC8147525
OpenAlexW3160450007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.