Evidence map›Paper›PMID 34055789›Full record

ArticleFrontiers in cell and developmental biology2021

Lucia A Torres-Fernández, Jana Emich, Yasmine Port, Sibylle Mitschka, Marius Wöste, Simon Schneider, Daniela Fietz, Manon S Oud, Sara Di Persio, Nina Neuhaus and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Germline stem cells in human.Signal transduction and targeted therapy · 2022
    Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Lucia A Torres-FernándezLife and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Jana EmichInstitute of Reproductive Genetics, University of Münster, Münster, Germany.
Yasmine PortLife and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Sibylle MitschkaLife and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Marius WösteInstitute of Medical Informatics, University of Münster, Münster, Germany.
Simon SchneiderInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Daniela FietzInstitute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University Gießen, Gießen, Germany.
Manon S OudDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands.
Sara Di PersioCentre of Reproductive Medicine and Andrology, Institute of Reproductive and Regenerative Biology, University Hospital Münster, Münster, Germany.
Nina NeuhausCentre of Reproductive Medicine and Andrology, Institute of Reproductive and Regenerative Biology, University Hospital Münster, Münster, Germany.
Sabine KlieschCentre of Reproductive Medicine and Andrology, Department of Clinical and Surgical Andrology, University Hospital Münster, Münster, Germany.
Michael HölzelInstitute of Experimental Oncology, University Hospital Bonn, Bonn, Germany.
Hubert SchorleInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Corinna FriedrichInstitute of Reproductive Genetics, University of Münster, Münster, Germany.
Frank TüttelmannInstitute of Reproductive Genetics, University of Münster, Münster, Germany.
Waldemar KolanusLife and Medical Sciences Institute, University of Bonn, Bonn, Germany.
University of Bonn · DEUniversity of Münster · DEUniversity Hospital Bonn · DEUniversity Hospital Münster · DERadboud University Nijmegen · NLUniversity of Giessen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations affecting the germline can result in infertility or the generation of germ cell tumors (GCT), highlighting the need to identify and characterize the genes controlling germ cell development. The RNA-binding protein and E3 ubiquitin ligase TRIM71 is essential for embryogenesis, and its expression has been reported in GCT and adult mouse testes. To investigate the role of TRIM71 in mammalian germ cell embryonic development, we generated a germline-specific conditional

Indexed as

azoospermiagerm cell tumors (GCT)Haystackinfertility/sterilitymammalian gonad developmentprimordial germ cells (PGCs)Sertoli cell-only (SCO) phenotypeTRIM71/LIN-41

Identifiers

PMID34055789
PMCPMC8155544
OpenAlexW3160764932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.