Evidence map›Paper›PMID 34055768›Full record

ArticleFrontiers in cell and developmental biology2021

Expression of Drosophila Matrix Metalloproteinases in Cultured Cell Lines Alters Neural and Glial Cell Morphology.

Scoty Hearst, Andrea Bednářová, Benjamin Draughn, Kennadi Johnson, Desiree Mills, Cendonia Thomas, Jendaya Scales, Eadie T Keenan, Jewellian V Welcher, Natraj Krishnan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Bone marrow stromal cells in Modic type 1 changes promote neurite outgrowth.Frontiers in cell and developmental biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Scoty HearstDepartment of Biology, Tougaloo College, Tougaloo, MS, United States.
Andrea BednářováDepartment of Biochemistry and Physiology, Institute of Entomology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czechia.
Benjamin DraughnDepartment of Chemistry and Biochemistry, Mississippi College, Clinton, MS, United States.
Kennadi JohnsonDepartment of Biology, Tougaloo College, Tougaloo, MS, United States.
Desiree MillsDepartment of Biology, Tougaloo College, Tougaloo, MS, United States.
Cendonia ThomasDepartment of Biology, Tougaloo College, Tougaloo, MS, United States.
Jendaya ScalesDepartment of Biology, Tougaloo College, Tougaloo, MS, United States.
Eadie T KeenanDepartment of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Starkville, MS, United States.
Jewellian V WelcherDepartment of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Starkville, MS, United States.
Natraj KrishnanDepartment of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Starkville, MS, United States.
Tougaloo College · USMississippi State University · USMississippi College · USInstitute of Entomology · CZ

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
NHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INIGMS NIH HHS P20 GM103476NIMHD NIH HHS HHSN268201800013I
6 · The paper itself

Abstract

Matrix metalloproteinases (MMPs) are zinc- and calcium- dependent endopeptidases that play pivotal roles in many biological processes. The expression of several MMPs in the central nervous system (CNS) have been shown to change in response to injury and various neurological/neurodegenerative disorders. While extracellular MMPs degrade the extracellular matrix (ECM) and regulate cell surface receptor signaling, the intracellular functions of MMPs or their roles in CNS disorders is unclear. Around 23 different MMPs are found in the human genome with overlapping function, making analysis of the intracellular role of human MMPs a daunting task. However, the fruit fly

Indexed as

apoptosisC6 glioblastomacell linedifferentiationDrosophila melanogastermatrix metalloproteinasesSH-SY5Y neuroblastoma

Identifiers

PMID34055768
PMCPMC8155609
OpenAlexW3162384228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.