ArticleBJPsych advances2021
The Immunology of Stress and the Impact of Inflammation on the Brain and Behavior.
Article in BJPsych advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 5 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Fibromyalgia in cancer patients: a systematic review and clinical implications for integrated care.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- Purpose in life and c-reactive protein: An individual-participant meta-analysis of >50,000 adults.Psychoneuroendocrinology · 2025Pooled it
- Risks to the Unborn: An Umbrella Review on the Effects of Prenatal Maternal Stress Caused by Natural Disasters.Stress and health : journal of the International Society for the Investigation of Stress · 2025Pooled it
- Pooled it
- Psychological eHealth Interventions for Patients With Cardiovascular Diseases: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Improving Cardiometabolic Health in Adolescent Girls With Elevated Anxiety: Web-Based Multisite, Pilot, and Feasibility Randomized Controlled Trial.JMIR cardio · 2026Trial
- Positive association between sex hormones and inflammatory cytokines in trauma-exposed premenopausal women.Brain, behavior, & immunity - health · 2026Article
- Temporal coupling of cortisol and immune cell responses in acute psychosocial stress.Brain, behavior, & immunity - health · 2026Article
- Long-term psychobiological stress responses following soft political repression.Scientific reports · 2026Article
- The Potential Pathway Among Self-Focused Attention, Rumination, Perceived Stress and Female Psychosomatic Symptoms.Behavioral sciences (Basel, Switzerland) · 2026Article
- Partner separation and sex contribute to anxiety-like behavior, but partner separation alone amplifies hippocampal inflammation following immune challenge.Brain, behavior, and immunity · 2026Article
- The Gut Microbiome in Early Ontogeny: Implications for Brain and Immune System Development.Journal of developmental biology · 2026Review
- An emerging theoretical lens post global epidemic and turmoil: Psychological immunity.Dialogues in health · 2026Review
- A wearable biosensing platform for continuous monitoring of inflammatory and metabolic biomarkers for real-time health tracking and personalized care.Bioengineering & translational medicine · 2026Article
- Association Between Allostatic Load and Incident Colorectal Cancer-A Prospective Study in a Multiethnic Asian Population.Cancer medicine · 2026Article
- Physical frailty, genetic risk, mediating biomarkers, and risk of suicide attempt: A prospective cohort study.PLoS medicine · 2026Article
- Novel epigenetic and transcriptomic profiles of immune, inflammatory, and cellular transduction pathways are associated with chronic perceived stress in midlife women.Brain, behavior, & immunity - health · 2026Article
- Stimulated cytokine production, attachment, and emotional well-being in dementia spousal caregivers.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Personalized resilience: how individual variability in brain-immune responses to stress influences the development of anxiety disorders.Frontiers in cellular neuroscience · 2026Review
- Response to immune-based augmentation treatment for depression: a potential role of immunosenescence.Neuroscience applied · 2026Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to acute versus chronic stressors and threats activates the immune system in adaptive and maladaptive manners, respectively. While acute activation of the immune system in response to threat is homeostatically regulated by glucocorticoid negative feedback, chronic activation of the immune system arising from persistent stress exposure can contribute to an allostatic load with an inflammatory diathesis that has been implicated in stress-related psychopathology, including of depression and anxiety. Increased inflammation in the periphery and in the brain arising from chronic stress exposure can alter neurotransmitter metabolism and impact activation of brain regions to increase adverse behavioral health symptoms (e.g. anhedonia, anxiety, fatigue) and emotion dysregulation. While interventions targeting the immune system and its downstream effects on the brain for the treatment of depression and other psychiatric disorders has been of great interest as they have shown some efficacy in treating stress-related behavioral health disorders, future studies are necessary to better characterize the contexts under which anti-inflammatory agents should be used to treat stress-related psychopathology.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.