Evidence map›Paper›PMID 34055225›Full record

ArticleACS medicinal chemistry letters2021

Discovery of 5-Nitro-6-thiocyanatopyrimidines as Inhibitors of

Maureen J Donlin, Thomas R Lane, Olga Riabova, Alexander Lepioshkin, Evan Xu, Jeffrey Lin, Vadim Makarov, Sean Ekins

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maureen J DonlinEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States.ORCID 0000-0001-7312-079X
Thomas R LaneCollaborations Pharmaceuticals, Inc., Raleigh, North Carolina 27606, United States.
Olga RiabovaDepartment of Biology, Saint Louis University, St. Louis, Missouri 63103, United States.
Alexander LepioshkinDepartment of Biology, Saint Louis University, St. Louis, Missouri 63103, United States.
Evan XuEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States.
Jeffrey LinDepartment of Biology, Saint Louis University, St. Louis, Missouri 63103, United States.
Vadim MakarovResearch Center of Biotechnology RAS, 119071 Moscow, Russia.
Sean EkinsCollaborations Pharmaceuticals, Inc., Raleigh, North Carolina 27606, United States.ORCID 0000-0002-5691-5790

Funding

Centralized assay datasets for modelling support of small drug discovery organizationsR44GM122196 · NIGMS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN · 2018 to 2022
$3.3M
ROLE OF CELL WALL INTEGRITY IN ECHINOCANDIN RESISTANCE IN C. NEOFORMANSR01AI123407 · NIAID · WASHINGTON UNIVERSITY · PI DONLIN, MAUREEN J, LODGE, JENNIFER K. · 2017 to 2021
$1.9M
New generation of non-nucleoside RT HIV inhibitors avoiding HIV-associated neurocognitive disordersR01NS102164 · NINDS · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN, NELSON, JULIE AE · 2017 to 2019
$587k
NIAID NIH HHS R01 AI123407NIGMS NIH HHS R44 GM122196NINDS NIH HHS R01 NS102164
6 · The paper itself

Abstract

Opportunistic infections from pathogenic fungi present a major challenge to healthcare because of a very limited arsenal of antifungal drugs, an increasing population of immunosuppressed patients, and increased prevalence of resistant clinical strains due to overuse of the few available antifungals. Cryptococcal meningitis is a life-threatening opportunistic fungal infection caused by one of two species in the

Identifiers

PMID34055225
PMCPMC8155264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.