Evidence map›Paper›PMID 34055117›Full record

ReviewPain research & management2021

Patient-Controlled Analgesia (PCA): Intravenous Administration (IV-PCA) versus Oral Administration (Oral-PCA) by Using a Novel Device (PCoA® Acute) for Hospitalized Patients with Acute Postoperative Pain-A Comparative Retrospective Study.

Stefan Wirz, Stefanie Seidensticker, Ronit Shtrichman

Open access · goldAbstract readComparative StudyReview
In one paragraph

Review in Pain research & management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stefan WirzDepartment of Anesthesiology, Interdisciplinary Intensive Care, Pain Medicine/Palliative Medicine, Center for Pain Medicine, Center for Weaning, GFO-Clinics Bonn/CURA Hospital, Bad Honnef, Germany.ORCID 0000-0001-8842-6679
Stefanie SeidenstickerDepartment of Anesthesiology, Interdisciplinary Intensive Care, Pain Medicine/Palliative Medicine, Center for Pain Medicine, Center for Weaning, GFO-Clinics Bonn/CURA Hospital, Bad Honnef, Germany.ORCID 0000-0002-4011-2942
Ronit ShtrichmanDosentrx Ltd., 2 Hamelacha Street, Har Tuv Industrial Zone A, Beit-Shemesh 9980101, Israel.ORCID 0000-0001-7559-6388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute postoperative pain delays recovery and increases morbidity and mortality. Opioid therapy is effective but is accompanied by adverse reactions. Patient-controlled analgesia (PCA) enables self-administration of analgesics. Oral-PCA is a safe and beneficial alternative to intravenous (IV) PCA. We have developed a novel Oral-PCA device, which enables self-administration of solid pills to the patient's mouth. This is a retrospective study comparing the effectiveness and usability of this novel Oral-PCA with those of IV-PCA. Methods: Medical records of patients who received PCA following gynecology and orthopedic surgeries were analyzed. The control cohort ( Results: Patient demographics, initial NRS, and PCA duration were comparable between cohorts. NRS reduction in rest and movement was stronger in the Oral-PCA cohort (rest: 1.61 and 2.27, Conclusions: Oral-PCA by using PCoA® Acute provides pain control and usability which is noninferior to the IV-PCA, as well as superior to pain reduction in rest and movement. These results, along with the noninvasiveness, medication flexibility, and reduced cost, suggest the potential of Oral-PCA, by using PCoA Acute, to replace IV-PCA for postoperative analgesia.

Indexed as

Administration, IntravenousAdministration, OralAdultAgedAged, 80 and overAnalgesia, Patient-ControlledAnalgesics, OpioidCohort StudiesFemaleGermanyHumansMaleMiddle AgedOxycodonePain ManagementPostoperative PainAnalgesics, OpioidOxycodone

Identifiers

PMID34055117
PMCPMC8112920
OpenAlexW3157277050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.