Evidence map›Paper›PMID 34055104›Full record

Observational studyDisease markers2021

Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19.

Mattia Bellan, Danila Azzolina, Eyal Hayden, Gianluca Gaidano, Mario Pirisi, Antonio Acquaviva, Gianluca Aimaretti, Paolo Aluffi Valletti, Roberto Angilletta, Roberto Arioli and 119 more

Abstract readObservational Study

PubMed Full text at PMC Publisher

In one paragraph

Observational study in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

17citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

Identification of Parameters Representative of Immune Dysfunction in Patients with Severe and Fatal COVID-19 Infection: a Systematic Review and Meta-analysis.Clinical reviews in allergy & immunology · 2023
Pooled it
The association between RDW-to-platelet ratio and in-hospital mortality in critically ill stroke patients: A retrospective cohort study based on the eICU database.PloS one · 2026
Article
The predictive role of inflammation indices derived from complete blood count in severe COVID-19 patients: a study from the United Arab Emirates.Frontiers in medicine · 2025
Article
The Evaluation of Laboratory Parameters as Predictors of Disease Severity and Mortality in COVID-19 Patients: A Retrospective Study From a Tertiary Care Hospital in India.Cureus · 2023
Article
COVID-19 Biomarkers at the Crossroad between Patient Stratification and Targeted Therapy: The Role of Validated and Proposed Parameters.International journal of molecular sciences · 2023
Review
Baseline Plasma Osteopontin Protein Elevation Predicts Adverse Outcomes in Hospitalized COVID-19 Patients.Viruses · 2023
Observational
Active regression model for clinical grading of COVID-19.Frontiers in immunology · 2023
Article
Clinical Characteristics and Predictors of In-Hospital Mortality of Patients Hospitalized with COVID-19 Infection.Journal of clinical medicine · 2022
Article
Long-Term Survival among Patients Hospitalized for COVID-19 during the First Three Epidemic Waves: An Observational Study in a Northern Italy Hospital.International journal of environmental research and public health · 2022
Observational
Predicting In-Hospital Mortality in Severe COVID-19: A Systematic Review and External Validation of Clinical Prediction Rules.Biomedicines · 2022
Article
CGRP Plasma Levels Correlate with the Clinical Evolution and Prognosis of Hospitalized Acute COVID-19 Patients.Viruses · 2022
Observational
Prognosing the risk of COVID-19 death through a machine learning-based routine blood panel: A retrospective study in Brazil.International journal of medical informatics · 2022
Article
Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein.Disease markers · 2022
Observational
The Prognostic Role of Metabolic and Endocrine Parameters for the Clinical Severity of COVID-19.Disease markers · 2022
Article
Early Prediction of Disease Progression in Patients with Severe COVID-19 Using C-Reactive Protein to Albumin Ratio.Disease markers · 2021
Article
Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19.Disease markers · 2021
Article
Hematological findings in COVID-19 and their correlation with severity of Disease.Pakistan journal of medical sciences
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

129 authors.

Mattia BellanUniversità del Piemonte Orientale UPO, Novara, Italy.

Danila AzzolinaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-8185-5742

Eyal HaydenUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-3246-8145

Gianluca GaidanoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-4681-0151

Mario PirisiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9740-0155

Antonio AcquavivaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-9165-5621

Gianluca AimarettiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-6186-0106

Paolo Aluffi VallettiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-4905-0132

Roberto AngillettaAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0003-1159-3019

Roberto ArioliUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-6638-8253

Gian Carlo AvanziUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-7611-8345

Gianluca AvinoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-2878-560X

Piero Emilio Balbo"AOU Maggiore della Carità", Novara, Italy.ORCID https://orcid.org/0000-0001-5300-3959

Giulia BaldonUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-8910-0539

Francesca BaordaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-9192-3948

Emanuela BarberoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-1494-0258

Alessio BaricichUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-8440-6283

Michela Barini"AOU Maggiore della Carità", Novara, Italy.ORCID https://orcid.org/0000-0003-4753-0431

Francesco Barone-AdesiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-1550-436X

Sofia BattistiniUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9392-7128

Michela BeltrameUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-1656-5482

Matteo BertoliUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-6936-4249

Stephanie BertolinUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-2233-3458

Marinella BertolottiAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0003-2152-4930

Marta BettiAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0002-1372-6666

Flavio Bobbio"AOU Maggiore della Carità", Novara, Italy.ORCID https://orcid.org/0000-0001-8850-8543

Paolo BoffanoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-0782-9933

Lucio BoglioneUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-8326-4930

Silvio Borrè"Sant'Andrea" Hospital, Vercelli, Italy.ORCID https://orcid.org/0000-0003-3170-437X

Matteo BrucoliUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-2867-1936

Elisa CalzaduccaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-4627-6470

Edoardo CammarataUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-7844-6956

Vincenzo CantaluppiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-4120-3555

Roberto CantelloUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-6999-5729

Andrea Capponi"AOU Maggiore della Carità", Novara, Italy.ORCID https://orcid.org/0000-0003-2822-3313

Alessandro CarrieroUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-7481-7169

Giuseppe Francesco CasciaroUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-1420-4058

Luigi Mario CastelloUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-8248-1976

Federico CerutiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-8540-0315

Guido ChichinoAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0001-8193-8815

Emilio ChiricoUniversità del Piemonte Orientale UPO, Novara, Italy.

Carlo CisariUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9424-736X

Micol Giulia CittoneUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-4400-1526

Crizia ColomboUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9943-8309

Cristoforo ComiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-6862-9468

Eleonora CroceUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9185-6215

Tommaso DaffaraUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-0483-3619

Pietro DannaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-8928-7666

Francesco Della CorteUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-1736-2318

Simona De VecchiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-4607-5844

Umberto DianzaniUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-6723-3931

Davide Di BenedettoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-3329-4634

Elia EspostoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-6791-5932

Fabrizio FaggianoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-2382-0848

Zeno FalaschiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-3583-2731

Daniela FerranteUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-4929-3759

Alice FerreroUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9464-3223

Ileana GagliardiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-8622-8123

Alessandra GalbiatiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-4511-5365

Silvia GalloUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-7223-2060

Pietro Luigi Garavelli"AOU Maggiore della Carità", Novara, Italy.ORCID https://orcid.org/0000-0002-3892-2532

Clara Ada GardinoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-5290-4226

Massimiliano GarzaroUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9949-1177

Maria Luisa GastaldelloUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-5459-7055

Francesco GavelliUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-0581-245X

Alessandra GennariUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-0928-2281

Greta Maria GiacominiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-5972-4626

Irene GiaconeUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-7506-0073

Valentina Giai ViaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-0357-8011

Francesca GiolittiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-3707-2273

Laura Cristina GironiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-7298-4446

Carla GramagliaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-5571-9133

Leonardo GrisafiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-5277-9907

Ilaria InserraUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-3915-7614

Marco InvernizziUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-5141-0681

Marco KrengliUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-2064-8379

Emanuela LabellaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-8548-8217

Irene Cecilia LandiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-1263-1718

Raffaella LandiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-0492-553X

Ilaria LeoneUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-4512-3990

Veronica LioUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-2773-5798

Luca LorenziniUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-8255-7157

Antonio MaconiAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0002-1904-7277

Mario MalerbaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-1246-4892

Giulia Francesca ManfrediUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-2399-5376

Maria MartelliUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-6234-1482

Letizia MarzariUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-1928-8724

Paolo MarzulloUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-3215-5747

Marco MennuniUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-3795-8787

Claudia MontaboneUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-9028-7038

Umberto MorosiniUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-3241-9485

Marco MussaAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0002-0330-4427

Ilaria NericiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-3713-4550

Alessandro NuzzoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-8657-2808

Carlo OlivieriUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-7858-8882

Samuel Alberto PadelliUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-6786-1196

Massimiliano PanellaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-1880-7198

Andrea ParisiniAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0002-6235-4379

Alessio PaschèUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-8560-3158

Filippo PatruccoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-4794-8734

Giuseppe PattiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-5404-3968

Alberto PauUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-4738-4801

Anita Rebecca PedrinelliUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-8390-9532

Ilaria PercivaleUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9388-8667

Luca RagazzoniUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-2528-4375

Roberta ReUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9669-2571

Cristina RigamontiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-2089-4139

Eleonora RizziUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-9615-2452

Andrea RognoniUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-6139-0263

Annalisa RovetaAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0003-2484-0963

Luigia Salamina"AOU Maggiore della Carità", Novara, Italy.ORCID https://orcid.org/0000-0002-7665-4890

Matteo SantagostinoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-4482-0839

Massimo SaracenoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-9954-7852

Paola SavoiaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-1636-8411

Marco SciarraAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0002-1077-3897

Andrea SchimmentiAzienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.ORCID https://orcid.org/0000-0003-1021-2931

Lorenza ScottiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-3861-9058

Enrico SpinoniUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-7980-1737

Carlo SmirneUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-3338-5416

Vanessa TarantinoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-5621-4441

Paolo Amedeo TillioUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-4451-038X

Stelvio TonelloUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-0836-0890

Rosanna VaschettoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-4625-4367

Veronica VassiaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-7097-0710

Domenico ZagariaUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-7070-5474

Elisa ZavattaroUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0003-4537-3014

Patrizia ZeppegnoUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-1990-0346

Francesca ZottarelliUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0002-1510-2291

Pier Paolo SainaghiUniversità del Piemonte Orientale UPO, Novara, Italy.ORCID https://orcid.org/0000-0001-8322-9158

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe clinical course of Coronavirus Disease 2019 (COVID-19) is highly heterogenous, ranging from asymptomatic to fatal forms. The identification of clinical and laboratory predictors of poor prognosis may assist clinicians in monitoring strategies and therapeutic decisions. MATERIALS AND

methodsIn this study, we retrospectively assessed the prognostic value of a simple tool, the complete blood count, on a cohort of 664 patients (

resultsAt data cut-off, 221/664 patients (33.3%) had died and 453/664 (66.7%) had been discharged. Red cell distribution width (RDW) (

conclusionOur findings arise the opportunity of stratifying COVID-19 severity according to simple lab parameters, which may drive clinical decisions about monitoring and treatment.

Indexed as

Blood Cell CountClinical Decision RulesHospital MortalitySeverity of Illness IndexAdultAgedAged, 80 and overCOVID-19FemaleHumansItalyMaleMiddle AgedMultivariate AnalysisPrognosisRetrospective Studies

Identifiers

PMID34055104

DOI10.1155/2021/8863053

PMCPMC8123088

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