Evidence map›Paper›PMID 34055070›Full record

ReviewExperimental and therapeutic medicine2021

Oxidative stress and peripartum outcomes (Review).

Zsuzsanna Simon-Szabo, Erzsebet Fogarasi, Eniko Nemes-Nagy, Lorand Denes, Mircea Croitoru, Bela Szabo

Registry-linked trialOpen access · diamondAbstract readReview
In one paragraph

Review in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07550309 (Longitudinal, Randomized, Parallel-Group, Controlled Clinical Study to Evaluate the Effectiveness of a Nutritional Education Intervention in Uncomplicated Pregnancy), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07550309 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Longitudinal, Randomized, Parallel-Group, Controlled Clinical Study to Evaluate the Effectiveness of a Nutritional Education Intervention in Uncomplicated Pregnancy

TypeinterventionalSponsorAzienda Sanitaria Locale CN2 Alba-BraRan2023 to 2026Enrolled216ConditionsPregnancy, Uncomplicated Pregnancy, Diet, Food and Nutrition, Weight Gain During PregnancyArmsStructured Nutritional Education Program, Routine Prenatal Care With Nutritional Information Brochure
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Oxidative stress biomarkers in pregnancy: a systematic review.Reproductive biology and endocrinology : RB&E · 2024
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Molecular Approach of Oxidative Stress and Bronchopulmonary Dysplasia: Relationship of GSTM1 and GSTT1 Genes.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
    Review
  14. Article
  15. [Role of reactive oxygen species/silent information regulator 1 in hyperoxia-induced bronchial epithelial cell injury].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zsuzsanna Simon-SzaboDepartment of Obstetrics-Gynecology, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania.
Erzsebet FogarasiDepartment of Toxicology and Biopharmacy, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania.
Eniko Nemes-NagyDepartment of Chemistry and Medical Biochemistry, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania.
Lorand DenesDepartment of Anatomy, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania.
Mircea CroitoruDepartment of Toxicology and Biopharmacy, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania.
Bela SzaboDepartment of Obstetrics-Gynecology, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania.
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy, labor and childbirth are accompanied by excessive oxidative aggression. The excessive formation of free radicals [reactive oxygen species (ROS), reactive nitrogen species (RNS), chlorine reactive species (CRS)] causes cellular oxidative damage, which can be scavenged by enzymatic or non-enzymatic antioxidants in normal healthy pregnancy, physiological labor and delivery without any complications. An imbalance between the pro-oxidant and antioxidant factors may lead to oxidative stress, which contributes to the development of many diseases. This oxidative aggression can be a precursor for pathologies in the pregnant woman including eclampsia, miscarriage, preterm labor, and intrauterine growth retardation; in the offspring it may lead to bronchopulmonary dysplasia/chronic lung disease, necrotizing enterocolitis, retinopathy of prematurity, and periventricular leukomalacia. This review summarizes the studies conducted to identify the mechanisms of oxidative stress and the effect of cell membrane oxidation, the mechanisms that are behind oxidative stress-related diseases, and also those studies which have demonstrated the effect of antioxidants in preventing diseases or diminishing the effects of oxidative stress in the body, in obstetrics and neonatology.

Indexed as

antioxidantsfree radicalsmalondialdehydeneonateoxidative stresspregnancypreterm

Identifiers

PMID34055070
PMCPMC8145513
OpenAlexW3163919773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.