Evidence map›Paper›PMID 34055025›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

Calycosin Alleviates Injury in Airway Epithelial Cells Caused by PM 2.5 Exposure via Activation of AMPK Signalling.

Chunyan Wang, Jingjing Luo, Xiaoxue Bai, Shucheng Hua, Jing Jie, Han Liu, Jinying Gao, Lei Song

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chunyan WangCadre's Wards, the First Hospital of Jilin University, Changchun 130021, Jilin, China.
Jingjing LuoDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, Jilin, China.
Xiaoxue BaiCadre's Wards, the First Hospital of Jilin University, Changchun 130021, Jilin, China.
Shucheng HuaCadre's Wards, the First Hospital of Jilin University, Changchun 130021, Jilin, China.ORCID https://orcid.org/0000-0002-4531-1537
Jing JieDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, Jilin, China.
Han LiuDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, Jilin, China.ORCID https://orcid.org/0000-0001-7940-4339
Jinying GaoDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, Jilin, China.ORCID https://orcid.org/0000-0001-7805-7865
Lei SongDepartment of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, Jilin, China.ORCID https://orcid.org/0000-0002-4115-065X
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

methodsPhospho-AMP-activated protein kinase (p-AMPK) and AMP-activated protein kinase (AMPK) were detected by western blot. Immunofluorescence staining was used to validate changes in the levels of nuclear factor kappa B (NF-

resultsAdministration of calycosin was increased in PM 2.5-treated B2B cells in a dose-dependent manner

conclusionsCalycosin effectively decreased the release of inflammatory cytokines and alleviated injury caused by PM 2.5. These effects were mediated through activation of AMPK to suppress NF-

Identifiers

PMID34055025
PMCPMC8112952
OpenAlexW3159048271

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.