ReviewInternational journal of dentistry2021
The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature.
Review in International journal of dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Inflammatory Association between Periodontal Disease and Systemic Health.Inflammation · 2025Pooled it
- Association between peri-implantitis and systemic inflammation: a systematic review.Frontiers in immunology · 2023Pooled it
- Biomarker-Guided Implant Maintenance (BGIM): A Narrative Review and Protocol Proposal.Journal of clinical medicine · 2026Review
- Dysregulation of the Immune System in Advanced Periimplantitis: Systemic Implications and Inflammatory Mechanisms-A Hematological and Immunological Study.Journal of clinical medicine · 2025Article
- Unraveling the Applicability of LbL Coatings for Drug Delivery in Dental Implant-Related Infection Treatment.ACS biomaterials science & engineering · 2025Review
- Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies.Frontiers in microbiology · 2025Review
- YAG laser combined with mechanical debridement enhances pain relief and inflammation control in the management of periodontitis with peri-implantitis.American journal of translational research · 2025Article
- Experimental peri-implantitis induces neuroinflammation: An exploratory study in rats.BMC oral health · 2024Article
- Article
- How Can Imbalance in Oral Microbiota and Immune Response Lead to Dental Implant Problems?International journal of molecular sciences · 2023Review
- Review
- Anti-Peri-implantitis Bacteria's Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study.European journal of dentistry · 2023Article
- In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review.Pharmaceutics · 2022Review
- Article
- The Potential Contribution of Dental Foci and Oral Mucositis to Febrile Neutropenia in Patients Treated With Myelosuppressive Chemotherapy for Solid Tumors and Lymphoma.Frontiers in oral health · 2022Article
- Reversal of Osseointegration as a Novel Perspective for the Removal of Failed Dental Implants: A Review of Five Patented Methods.Materials (Basel, Switzerland) · 2021Review
- In vitro assessment of the effect of probiotic lactobacillus reuteri on peri-implantitis microflora.BMC oral health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While periodontitis has been proven to have an impact on systemic conditions, such as cardiovascular diseases, pregnancy complications, or poor glycemic control in diabetic patients, the influence of peri-implantitis on systemic health has not been adequately explored in the literature as yet. The existing evidence suggests that peri-implant lesions lead to more intense inflammatory response than periodontitis. Given the analogies between periodontal diseases and peri-implantitis, the aim of the present paper was to review the scientific evidence about the potential correlation between peri-implantitis and systemic diseases and conditions. Two clinical trials on animals reported that experimental peri-implantitis determined an alteration in hematological and biological parameters. One human study explored the risk indicators for cardiovascular diseases and found that patients with peri-implantitis had significantly higher levels of triglyceride, uric acid, and white blood cells and lower levels of vitamin D. It was described in the literature that periodontitis affects cardiovascular health through a number of mechanisms, including the increase in systemic mediators of inflammation, which also has a role in the worsening of glycemic control in diabetic patients. Similarly, peri-implantitis may influence the systemic status through inflammatory cytokines such as IL-1, IL-6, and IL-10 and matrix metalloproteinases. One microbiological mechanism, based on the systemic dissemination of periodontal bacteria, has been hypothesized for cardiovascular diseases and pregnancy complications. Again, it is plausible that the same could occur in peri-implantitis. In conclusion, only few studies explored the systemic impact of peri-implantitis. Although changes in hematological parameters, biochemical parameters, and inflammatory markers have been reported in peri-implantitis, further studies are needed to investigate this correlation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.